SynthesisPloS one2022
Identified risk factors for dry eye syndrome: A systematic review and meta-analysis.
Synthesis in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07185854 (Acupuncture Combined With Artificial Tears Compared With Artificial Tears Alone in Moderate Dry Eye), which is not on this map. Cited by 75 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Acupuncture Combined With Artificial Tears Compared With Artificial Tears Alone in Moderate Dry Eye: A Randomized Controlled Trial
Who cites it
75 citing papers in PubMed, 2 syntheses or guidelines pooled it, 134 citations in OpenAlex.
- Association between dry mouth and dry eyes: a systematic literature review of clinical evidence.Rheumatology international · 2025Pooled it
- Topical diquafosol versus hyaluronic acid for the treatment of dry eye disease: a meta-analysis of randomized controlled trials.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Pooled it
- Trial
- Omega-3 fatty acids supplements for dry eye - Are they effective or ineffective?Indian journal of ophthalmology · 2023Trial
- Evaluation of the effect of patching therapy on dry eye tests and tear film osmolarity in children with amblyopia.BMC ophthalmology · 2026Article
- Epiphora: A Structured Diagnostic Approach for the Otolaryngologist.World journal of otorhinolaryngology - head and neck surgery · 2026Review
- The burden of keratoconjunctivitis sicca in Nigeria: a scoping review of prevalence and risk factors.International ophthalmology · 2026Article
- Differential Characteristics, Mechanisms, and Clinical Strategies for Perioperative Dry Eye in Presenile Cataract and Age-Related Cataract.Healthcare (Basel, Switzerland) · 2026Review
- Anisometropia and Its Related Traits: Ocular, Systemic, and Genetic Characteristics-Results From the Gutenberg Health Study.Investigative ophthalmology & visual science · 2026Article
- New healthcare insights in ophthalmology: using a data integration center (DIC) to analyze the care of patients with corneal ulceration during the COVID-19 pandemic.International ophthalmology · 2026Article
- Prevalence, severity and associated risk factors of symptomatic dry eye among breast cancer patients receiving systemic therapy in Palestine.Scientific reports · 2026Article
- Systemic and Metabolic Profile of Sagging Eye Syndrome: A Comparative Analysis.American journal of ophthalmology · 2026Article
- Prevalence and predictors of dry eye syndrome among the young population in Jordan: A cross-sectional survey study.Medicine · 2026Article
- Prevalence and severity of dry eye disease among ophthalmologists, optometrists, and nurses: a cross-sectional questionnaire-based survey.International ophthalmology · 2026Article
- Benchmark evaluation of video large language models in quality assessment of science popularization videos for dry eye.Scientific reports · 2026Article
- Diagnostic Agreement Between Invasive and Non-invasive Assessments for Preoperative Dry Eye Disease Screening in Patients with Cataracts.Ophthalmology and therapy · 2026Article
- Bisphenol A exacerbates dry eye disease via the CASP1/GSDMD-mediated pyroptotic axis: network toxicology, mendelian randomization, and experimental validation.Frontiers in pharmacology · 2026Article
- 3% diquafosol sodium combined with 0.1% fluorometholone for postoperative dry eye in pterygium patients with preoperative tear deficiency: a pilot retrospective study.Frontiers in medicine · 2026Article
- Article
- The Link between Obstructive Sleep Apnea and Dry Eye Disease: Pathophysiology and Current Updates.Ophthalmic research · 2026Review
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A meta-analytic approach was used to identify potential risk factors for dry eye syndrome. PubMed, Embase, and the Cochrane library were systematically searched for studies investigated the risk factors for dry eye syndrome from their inception until September 2021. The odds ratio (OR) with 95% confidence interval (CI) was calculated using the random-effects model. Forty-eight studies comprising 493,630 individuals were included. Older age (OR: 1.82; P<0.001), female sex (OR: 1.56; P<0.001), other race (OR: 1.27; P<0.001), visual display terminal use (OR: 1.32; P<0.001), cataract surgery (OR: 1.80; P<0.001), contact lens wear (OR: 1.74; P<0.001), pterygium (OR: 1.85; P = 0.014), glaucoma (OR: 1.77; P = 0.007), eye surgery (OR: 1.65; P<0.001), depression (OR: 1.83; P<0.001), post-traumatic stress disorder (OR: 1.65; P<0.001), sleep apnea (OR: 1.57; P = 0.003), asthma (OR: 1.43; P<0.001), allergy (OR: 1.38; P<0.001), hypertension (OR: 1.12; P = 0.004), diabetes mellitus (OR: 1.15; P = 0.019), cardiovascular disease (OR: 1.20; P<0.001), stroke (OR: 1.32; P<0.001), rosacea (OR: 1.99; P = 0.001), thyroid disease (OR: 1.60; P<0.001), gout (OR: 1.40; P<0.001), migraines (OR: 1.53; P<0.001), arthritis (OR: 1.76; P<0.001), osteoporosis (OR: 1.36; P = 0.030), tumor (OR: 1.46; P<0.001), eczema (OR: 1.30; P<0.001), and systemic disease (OR: 1.45; P = 0.007) were associated with an increased risk of dry eye syndrome. This study reported risk factors for dry eye syndrome, and identified patients at high risk for dry eye syndrome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.