Evidence map›Paper›PMID 35984776›Full record

ArticleApplied neuropsychology. Adult

Source recognition discriminability impairment in Huntington's versus Alzheimer's disease: Evidence from the CVLT-3.

Lisa V Graves, Emma G Churchill, McKenna E Williams, Emily J Van Etten, Mark W Bondi, David P Salmon, Jody Corey-Bloom, Dean C Delis, Paul E Gilbert

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied neuropsychology. Adult. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Lisa V GravesDepartment of Psychology, California State University San Marcos, San Marcos, CA, USA.
Emma G ChurchillDepartment of Psychology, San Diego State University, San Diego, CA, USA.
McKenna E WilliamsSDSU/UC San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
Emily J Van EttenDepartment of Psychology, University of Arizona, Tucson, AZ, USA.
Mark W BondiVeterans Affairs San Diego Healthcare System, San Diego, CA, USA.
David P SalmonDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Jody Corey-BloomDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Dean C DelisDepartment of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA, USA.
Paul E GilbertDepartment of Psychology, San Diego State University, San Diego, CA, USA.
University of California, San Diego · USCalifornia State University, San Marcos · USSan Diego State University · USUniversity of Arizona · US

Funding

UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Mark W Bondi · 2019 to 2026
$34.9M
Re-visiting Methods for MCI Diagnosis to Improve Biomarker and Trial FindingsR01AG049810 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BONDI, MARK W, EDLAND, STEVEN DYAL · 2016 to 2020
$3.7M
Mnemonic Processing Deficits in Older Adults at Risk for Alzheimer's DiseaseR01AG034202 · NIA · SAN DIEGO STATE UNIVERSITY · PI GILBERT, PAUL E · 2011 to 2015
$1.1M
NIA NIH HHS P30 AG062429NIA NIH HHS R01 AG034202NIA NIH HHS R01 AG049810
6 · The paper itself

Abstract

Research suggests that individuals with Huntington's disease (HD) perform better than individuals with Alzheimer's disease (AD) on the California Verbal Learning Test (CVLT) Yes/No Recognition trial. However, those with HD have been shown to have deficits comparable to those with AD on the Source Recognition Discriminability (RD) index (which assesses the ability to distinguish between List A targets and List B distractors), suggesting that HD may involve selective impairment in aspects of yes/no recognition that rely on source memory. However, whether individuals with HD and AD show comparable deficits on Source RD across stages of dementia severity has not been adequately investigated. We examined performance on the CVLT-3 List A vs. List B RD index in individuals with HD or AD and mild or moderate dementia. Among individuals with mild dementia, scores were higher in the HD versus AD group, whereas among individuals with moderate dementia, scores were comparable between the HD and AD groups; this corresponded to differential performance across dementia stages among individuals with HD, but not AD. The present findings suggest that, relative to AD, HD may be associated with disproportionate decline in aspects of yes/no recognition that rely on source memory.

Indexed as

Alzheimer DiseaseHuntington DiseaseRecognition, PsychologyAgedFemaleHumansMaleMiddle AgedNeuropsychological TestsVerbal LearningAlzheimer’s diseaseCalifornia Verbal Learning TestHuntington’s diseasememory deficitsmemory disorderrecognition

Identifiers

PMID35984776
PMCPMC9938836
OpenAlexW4292366957

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.