ArticleGut microbes
Gut-derived bacterial flagellin induces beta-cell inflammation and dysfunction.
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Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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0cells of the map it votes in
24citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 27 citations in OpenAlex.
- Nationwide cohort study reveals low bifidobacteria and distinct microbiota composition and function in Swedish newborns.Gut microbes · 2026Observational
- Metabolic-inflammatory memory: the common pathological basis and therapeutic targets of metabolic syndrome.Reviews in endocrine & metabolic disorders · 2026Review
- Lipid Metabolic Disorders: a Pivotal Driver in Type 2 Diabetes Mellitus Pathogenesis.Current obesity reports · 2026Review
- Angptl4 integrates dietary and microbial signals to disrupt gut barrier function in MASH.Nature communications · 2026Article
- Decoding the gut microbiota-immune dialogue: from bidirectional axis to therapeutic applications.Journal of nanobiotechnology · 2026Review
- Gut Microbiota and Metabolic Health: From Dysbiosis to Therapeutics.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026Review
- Microbe-associated molecular patterns differentially mediate carcinogenic alterations of the breast tissue in the context of obesity.Neoplasia (New York, N.Y.) · 2026Article
- Macrophage-mediated metabolic dysregulation in the pancreas: Insights from obesity.World journal of biological chemistry · 2025Review
- The role of the beta cell in type 2 diabetes: new findings from the last 5 years.Diabetologia · 2025Review
- Physiological Mechanisms of and Therapeutic Approaches to the Gut Microbiome and Low-Grade Inflammation in Obesity.Current issues in molecular biology · 2025Review
- Review
- Postbiotic Impact on Host Metabolism and Immunity Provides Therapeutic Potential in Metabolic Disease.Endocrine reviews · 2025Review
- SFB flagellin mediates cell adhesion, endocytosis and immune regulation in germ-free mice.Frontiers in immunology · 2025Article
- Immune cells: the key mediator between the gut microbiota and osteoporosis.Frontiers in immunology · 2025Review
- Harnessing Prebiotics to Improve Type 2 Diabetes Outcomes.Nutrients · 2024Review
- The bacterial flagellum as an object for optical trapping.Biophysical reviews · 2024Review
- Aging Gut Microbiome in Healthy and Unhealthy Aging.Aging and disease · 2024Review
- Review
- Role of pattern recognition receptors and microbiota-derived ligands in obesity.Frontiers in microbiomes · 2024Review
- Microbial sensing in the intestine.Protein & cell · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 6 institutions in 4 countries.
Torsten P M ScheithauerDepartment of (Experimental) Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0003-1446-3180
Hilde HerremaDepartment of (Experimental) Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Hongbing YuDepartment of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, and BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.
Guido J BakkerDepartment of (Experimental) Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Maaike WinkelmeijerDepartment of (Experimental) Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Galina SoukhatchevaDepartments of Surgery and Pathology and Laboratory Medicine Pathology and Laboratory Medicine, BC Children's Hospital Research Institute, Centre for Molecular Medicine & Therapeutics, Vancouver, British Columbia, Canada.
Derek DaiDepartments of Surgery and Pathology and Laboratory Medicine Pathology and Laboratory Medicine, BC Children's Hospital Research Institute, Centre for Molecular Medicine & Therapeutics, Vancouver, British Columbia, Canada.
Caixia MaDepartment of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, and BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.
Stefan R HavikDepartment of (Experimental) Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Manon BalversDepartment of (Experimental) Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Mark DavidsDepartment of (Experimental) Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Abraham S MeijnikmanDepartment of (Experimental) Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Ömrüm AydinDepartment of (Experimental) Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Bert-Jan H van den BornDepartment of (Experimental) Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Marc G BesselinkDepartment of Surgery, Amsterdam UMC, University of Amsterdam, Cancer Center Amsterdam, the Netherlands.
Olivier R BuschDepartment of Surgery, Amsterdam UMC, University of Amsterdam, Cancer Center Amsterdam, the Netherlands.
Maurits de BrauwDepartment of Surgery, Spaarne Gasthuis, Hoofddorp, The Netherlands.
Arnold van de LaarDepartment of Surgery, Spaarne Gasthuis, Hoofddorp, The Netherlands.
Clara BelzerLaboratory of Microbiology, Wageningen University and Research, Wageningen, The Netherlands.
Martin StahlDepartment of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, and BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.
Willem M de VosLaboratory of Microbiology, Wageningen University and Research, Wageningen, The Netherlands.
Bruce A VallanceDepartment of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, and BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.
Max NieuwdorpDepartment of (Experimental) Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
C Bruce VerchereDepartments of Surgery and Pathology and Laboratory Medicine Pathology and Laboratory Medicine, BC Children's Hospital Research Institute, Centre for Molecular Medicine & Therapeutics, Vancouver, British Columbia, Canada.
Daniël H van RaalteDepartment of (Experimental) Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Amsterdam University Medical Centers · NLBC Children's Hospital · CADiabetes Australia · AUSpaarne Ziekenhuis · NLUniversity of Helsinki · FIWageningen University & Research · NL
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperglycemia and type 2 diabetes (T2D) are caused by failure of pancreatic beta cells. The role of the gut microbiota in T2D has been studied, but causal links remain enigmatic. Obese individuals with or without T2D were included from two independent Dutch cohorts. Human data were translated
Indexed as
Diabetes Mellitus, Type 2FlagellinGastrointestinal MicrobiomeInsulin-Secreting CellsAnimalsBacterial ProteinsHumansInflammationInsulinMiceBacterial ProteinsFlagellinInsulinbeta-cell functionflagellinGut microbiotainflammationtype 2 diabetes
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.