Evidence map›Paper›PMID 35984521›Full record

Trial reportSurgical endoscopy2023

Bowel stimulation before loop ileostomy closure to reduce postoperative ileus: a multicenter, single-blinded, randomized controlled trial.

Richard Garfinkle, Marie Demian, Sarah Sabboobeh, Jeongyoon Moon, Michael Hulme-Moir, A Sender Liberman, Stan Feinberg, Dana M Hayden, Sami A Chadi, Sebastian Demyttenaere and 9 more

2 registry-linked trialsOpen access · hybridAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Surgical endoscopy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06974500 recruitingnot on this mapstarted 2025, after this paper: background citation

Implementation of an Efferent Loop Stimulation Protocol Prior to Ileostomy Closure at La Paz University Hospital

Typeobservational_patient_registrySponsorHospital Universitario La PazRan2025 to 2027Enrolled68ConditionsPostoperative Ileus, Colorectal Cancer Control and Prevention, Stoma - IleostomyArmsDaily efferent limb stimulation for at least two weeks prior to surgery using saline solution and a thickering agent
NCT07640113 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

The STIMIC Trial: A Multicenter Randomized Control Trial Evaluating the Impact of Ambulatory Physiological Stimulation of the Efferent Limb Prior to Ileostomy Closure on Colorectal Microbiota Composition and Histopathological Findings

TypeinterventionalSponsorHospital Clinic of BarcelonaRan2026 to 2028Enrolled90ConditionsIleostomy Stoma, Stoma Stimulation, Microbiome AnalysisArmsSerum stimulation, Physiological stimulation
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. The ILEOSTIM trial: A multicentre randomised controlled trial evaluating the impact of efferent loop stimulation prior to ileostomy reversal on postoperative ileus.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 3 countries.

Richard GarfinkleDivision of Colon and Rectal Surgery, Jewish General Hospital, Montreal, QC, Canada.
Marie DemianDivision of Colon and Rectal Surgery, Jewish General Hospital, Montreal, QC, Canada.
Sarah SabboobehDivision of Colon and Rectal Surgery, Jewish General Hospital, Montreal, QC, Canada.
Jeongyoon MoonDivision of Colon and Rectal Surgery, Jewish General Hospital, Montreal, QC, Canada.
Michael Hulme-MoirDepartment of Surgery, North Shore Hospital, Auckland, New Zealand.
A Sender LibermanDepartment of Surgery, McGill University Health Center, Montreal, Canada.
Stan FeinbergDepartment of Surgery, North York General Hospital, Toronto, Canada.
Dana M HaydenDivision of Colon and Rectal Surgery, Rush University Medical Center, Chicago, USA.
Sami A ChadiDepartment of Surgery, University Health Network, Toronto, Canada.
Sebastian DemyttenaereDepartment of Surgery, St. Mary's Hospital, Montreal, Canada.
Louise SamuelDepartment of Nursing, Jewish General Hospital, Montreal, Canada.
Nevart HotakorzianDepartment of Nursing, Jewish General Hospital, Montreal, Canada.
Laurence QuintinDepartment of Nursing, Jewish General Hospital, Montreal, Canada.
Nancy MorinDivision of Colon and Rectal Surgery, Jewish General Hospital, Montreal, QC, Canada.
Julio FariaDivision of Colon and Rectal Surgery, Jewish General Hospital, Montreal, QC, Canada.
Gabriela GhitulescuDivision of Colon and Rectal Surgery, Jewish General Hospital, Montreal, QC, Canada.
Carol-Ann VasilevskyDivision of Colon and Rectal Surgery, Jewish General Hospital, Montreal, QC, Canada.
Marylise BoutrosDivision of Colon and Rectal Surgery, Jewish General Hospital, Montreal, QC, Canada. marylise.boutros@mcgill.ca.ORCID 0000-0001-8006-321X
Bowel Stimulation Research Collaborative
Jewish General Hospital · CAMcGill University Health Centre · CANorth Shore Hospital · NZNorth York General Hospital · CARush University Medical Center · USSt Mary's Hospital Centre · CAUniversity Health Network · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe objective of this study was to evaluate the impact of preoperative bowel stimulation on the development of postoperative ileus (POI) after loop ileostomy closure.

methodsThis was a multicenter, randomized controlled trial (NCT025596350) including adult (≥ 18 years old) patients who underwent elective loop ileostomy closure at 7 participating hospitals. Participants were randomly assigned (1:1) using a centralized computer-generated sequence with block randomization to either preoperative bowel stimulation or no stimulation (control group). Bowel stimulation consisted of 10 outpatient sessions within the 3 weeks prior to ileostomy closure and was performed by trained Enterostomal Therapy nurses. The primary outcome was POI, defined as an intolerance to oral food in the absence of clinical or radiological signs of obstruction, on or after postoperative day 3, that either (a) required nasogastric tube insertion; or (b) was associated with two of the following: nausea/vomiting, abdominal distension, or the absence of flatus.

resultsBetween January 2017 and November 2020, 101 patients were randomized, and 5 patients never underwent ileostomy closure; thus, 96 patients (47 stimulated vs. 49 control) were analyzed according to a modified intention-to-treat protocol. Baseline characteristics were well balanced in both groups. The incidence of POI was lower among patients randomized to stimulation (6.4% vs. 24.5%, p = 0.034; unadjusted RR: 0.26, 95% CI 0.078-0.87). Stimulated patients also had earlier median time to first flatus (2.0 days (1.0-2.0) vs. 2.0 days (2.0-3.0), p = 0.025), were more likely to pass flatus on postoperative day 1 (46.8% vs. 22.4%, p = 0.022), and had a shorter median postoperative hospital stay (3.0 days (2.0-3.5) vs. 4.0 days (2.0-6.0), p = 0.003).

conclusionsPreoperative bowel stimulation via the efferent limb of the ileostomy reduced POI after elective loop ileostomy closure.

Indexed as

IleostomyIleusAdolescentAdultFlatulenceHumansIntestinesPostoperative ComplicationsBowel stimulationLength of stayLoop ileostomy closurePostoperative ileus

Identifiers

PMID35984521
PMCPMC9390101
OpenAlexW4292855123

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.