Observational studyAnnals of the American Thoracic Society2023
Airway Inflammation in Children with Primary Ciliary Dyskinesia.
Registry-linked trialOpen access · greenAbstract readObservational StudyMulticenter Study
In one paragraph
Observational study in Annals of the American Thoracic Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06959251 (A Randomized, Placebo-controlled Clinical Trial Evaluating the Efficacy and Safety of Glycine and Magnesium+Thiamine Supplements, Alone or Combined, Administered for 6 Months to Patients With Primary Ciliary Dyskinesia), which is not on this map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized, Placebo-controlled Clinical Trial Evaluating the Efficacy and Safety of Glycine and Magnesium+Thiamine Supplements, Alone or Combined, Administered for 6 Months to Patients With Primary Ciliary Dyskinesia
Who cites it
19 citing papers in PubMed, 21 citations in OpenAlex.
- Pulmonary exacerbations in primary ciliary dyskinesia.European journal of pediatrics · 2026Review
- Pulmonary Exacerbations and Treatment in PCD: A Narrative Review.Pediatric pulmonology · 2026Review
- The association between chronic rhinosinusitis, bronchiectasis and type 2 inflammation: an EMBARC registry analysis.ERJ open research · 2026Article
- Xenon-129 magnetic resonance: a paradigm shift, an expensive toy or another tool for the pulmonologist?ERJ open research · 2026Article
- High rate of pulmonary exacerbations and neutrophilic airway inflammation in children with repaired esophageal atresia with or without tracheoesophageal fistula.Pediatric research · 2026Article
- Function and Structure Relationships With Inflammation Differ in Two Chronic Suppurative Lung Diseases.Pediatric pulmonology · 2026Article
- [18F]FDG PET/MR to assess disease extension and inflammation in children and young adults with primary ciliary dyskinesia.European journal of nuclear medicine and molecular imaging · 2026Article
- Changes in sputum viscoelastic properties and airway inflammation in primary ciliary dyskinesia are comparable to cystic fibrosis on elexacaftor/tezacaftor/ivacaftor therapy.The European respiratory journal · 2026Article
- Sputum from Individuals with Primary Ciliary Dyskinesia Drives M2-like Macrophage Polarization.Lung · 2026Article
- STAT3-Dependent Regulation of CFTR and Ciliogenesis Is Essential for Mucociliary Clearance and Innate Airway Defense in Hyper-IgE Syndrome.American journal of respiratory and critical care medicine · 2025Article
- Efficacy and safety of Qingbu Weijing decoction in treatment stable bronchiectasis: study protocol for a multicenter, double- blind, randomized and placebo-controlled trial.BMC complementary medicine and therapies · 2025Article
- Investigating cigarette smoke-induced airway inflammation and sperm activity impairment in rats based on cilia-associated proteins.3 Biotech · 2025Article
- Beyond the present: current and future perspectives on the role of infections in pediatric PCD.Frontiers in pediatrics · 2025Review
- Comparison of Longitudinal Outcomes in Children with Primary Ciliary Dyskinesia and Cystic Fibrosis.Annals of the American Thoracic Society · 2024Observational
- Associations between respiratory pathogens and lung function in primary ciliary dyskinesia: cross-sectional analysis from the PROVALF-PCD cohort.ERJ open research · 2024Article
- Airway specific deregulation of asthma-related serpins impairs tracheal architecture and oxygenation in D. melanogaster.Scientific reports · 2024Article
- Azithromycin promotes proliferation, and inhibits inflammation in nasal epithelial cells in primary ciliary dyskinesia.Scientific reports · 2023Article
- Article
- Preventing Continuous Damage in Primary Ciliary Dyskinesia: Is Airway Inflammation a Potential Target?Annals of the American Thoracic Society · 2023Article
Corrections and comments
- Commented on by
Authors and funding
12 authors at 7 institutions in 3 countries.
Scott D SagelDepartment of Pediatrics, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, Colorado.ORCID 0000-0001-6172-4465
Oren KupferDepartment of Pediatrics, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Brandie D WagnerDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Denver, Aurora, Colorado.
Stephanie D DavisDepartment of Pediatrics and.
Sharon D DellDepartment of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0003-2169-9407
Thomas W FerkolDepartment of Pediatrics, Washington University School of Medicine, St. Louis, Missouri.
Jordana E HoppeDepartment of Pediatrics, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Margaret RosenfeldDepartment of Pediatrics, Children's Hospital and Regional Medical Center, Seattle, Washington; and.
Kelli M SullivanDepartment of Medicine, Marsico Lung Institute, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
Harm A W M TiddensDepartment of Pediatric Pulmonology and Allergology, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands.
Michael R KnowlesDepartment of Medicine, Marsico Lung Institute, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
Margaret W LeighDepartment of Pediatrics and.
Children's Hospital Colorado · USUniversity of North Carolina at Chapel Hill · USColorado School of Public Health · USErasmus MC - Sophia Children’s Hospital · NLSeattle Children's Hospital · USUniversity of British Columbia · CAWashington University in St. Louis · US
Funding
The Impact of COVID-19 on People Living with Rare Diseases and Their FamiliesU2CTR002818 · NCATS · CINCINNATI CHILDRENS HOSP MED CTR · PI Michal Kouril · 2019 to 2026
$51.2MNIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1MLongitudinal Characterization of Respiratory Tract Exacerbations and Treatment Responses in Primary Ciliary DyskinesiaU54HL096458 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FERKOL, THOMAS W · 2009 to 2023
$20.0MNCATS NIH HHS U2C TR002818NCATS NIH HHS UL1 TR002535NHLBI NIH HHS U54 HL096458
Abstract
PubMed holds no abstract for this paper.
Indexed as
BronchiectasisCiliary Motility DisordersLung DiseasesAdolescentChildCytokinesDyneinsFemaleHumansInflammationLeukocyte ElastasePeptide HydrolasesSputumTumor Necrosis Factor-alphaCytokinesDyneinsLeukocyte ElastasePeptide HydrolasesTumor Necrosis Factor-alphabiomarkersbronchiectasisinflammationlung functionsputum
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT06959251ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.