ArticleMolecular nutrition & food research2022
The Effect of Infant Gastric Digestion on Human Maternal Milk Cells.
Article in Molecular nutrition & food research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Maternal milk cell components are uptaken by infant liver macrophages via extracellular vesicle mediated transport.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Article
- The contributions of parental lactation on offspring development: It's not udder nonsense!Hormones and behavior · 2023Review
- Metabolomic Diversity of Human Milk Cells over the Course of Lactation-A Preliminary Study.Nutrients · 2023Article
- The Effect of Infant Gastric Digestion on Human Maternal Milk Cells.Molecular nutrition & food research · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
scopeHuman breast milk contains a variety of cell types that have potential roles in infant immunity and development. One challenge associates with defining the purpose(s) of milk cells in the infant is a poor understanding of the effect of digestion on cell fate. METHODS AND
resultsThis study first demonstrates that milk cell death occurs after gastric digestion in mice. Then flow cytometry and RT-PCR are used to understand the mechanism of human milk cell death and quantify live cell types before and after simulated gastric digestion. This study finds that digestion in simulated gastric fluid for 30 min reduces cell viability from 72% to 27%, with most cell death is caused by the acidic pH. The primary mechanism of cell death is caspase-mediated apoptosis. The non-cellular components of milk offer only mild protection against cell death from stomach acid.
conclusionsGastric digestion does not select for a specific resilient cell population to survive-most cell types die in equal proportions in the gastric environment. Taken together, these results provide a foundation with which to understand the fate of human breast milk cells in the infant's intestine and beyond.
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Registered trials
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