SynthesisEuropean journal of pain (London, England)2022
Glucocorticoid treatment in patients with complex regional pain syndrome: A systematic review.
Synthesis in European journal of pain (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Guidelines on the Use of Therapeutic Apheresis in Clinical Practice-Evidence-Based Approach From the Writing Committee of the American Society for Apheresis: The Tenth Special Issue.Journal of clinical apheresis · 2026Guideline
- Interventions for treating pain and disability in adults with complex regional pain syndrome- an overview of systematic reviews.The Cochrane database of systematic reviews · 2023Pooled it
- Glucocorticoid treatment in patients with complex regional pain syndrome: A systematic review.European journal of pain (London, England) · 2022Pooled it
- Effect of Prednisolone on Clinical and Cytokine mRNA Profiling in Complex Regional Pain Syndrome.Journal of molecular neuroscience : MN · 2024Trial
- [Prospective, multicenter study of the outcome of complex regional pain syndrome after 12 months].Schmerz (Berlin, Germany) · 2026Article
- Long-Term Outcome of Complex Regional Pain Syndrome versus Limb Pain of Other Origin: Results From a Telephone Survey With up to 5-year Follow-Up.Pain research & management · 2026Article
- Spinal manipulative therapy promotes nucleus pulposus resorption and alleviates pain in a rat model of lumbar disc herniation via JNK-dependent regulation of inflammation and tissue remodeling.American journal of translational research · 2026Article
- Glial Activation, Neuroinflammation, and Loss of Neuroprotection in Chronic Pain: Cellular Mechanisms and Emerging Therapeutic Strategies.Biomedicines · 2025Review
- Efficacy of Immunotherapy for Complex Regional Pain Syndrome: A Narrative Review.Current pain and headache reports · 2025Review
- 10. Complex regional pain syndrome.Pain practice : the official journal of World Institute of Pain · 2025Review
- The Effect of Dexamethasone Administration on Postoperative Pain Following Laparoscopic Cholecystectomy: A Double-Blind Randomized Clinical Trial.Advanced biomedical research · 2025Article
- Integrating nociplastic pain into neuropathic pain framework: a proposal for a revised classification.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- Interventional Physiatry in the Complex Regional Pain Syndrome of the Upper Limb Following Herpes Zoster.Cureus · 2024Article
- Efficacy and Safety of Pharmacological Treatment in Patients with Complex Regional Pain Syndrome: A Systematic Review and Meta-Analysis.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Evidence of a genetic background predisposing to complex regional pain syndrome type 1.Journal of medical genetics · 2024Article
- Is there an association between serum soluble interleukin-2 receptor levels and syndrome severity in persistent Complex Regional Pain Syndrome?Pain medicine (Malden, Mass.) · 2023Article
- Review
- A retrospective review of the management and outcomes of patients diagnosed with complex regional pain syndrome type II using electrodiagnostic findings.Canadian journal of pain = Revue canadienne de la douleur · 2023Article
- Effectiveness of Infliximab in Patients with Complex Regional Pain Syndrome: A Case Series.Journal of pain research · 2023Article
- The Role of Neuroinflammation in Complex Regional Pain Syndrome: A Comprehensive Review.Journal of pain research · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveThe pathophysiology of complex regional pain syndrome (CRPS) is multifactorial, with an exaggerated inflammatory response being the most prominent. Treatment for CRPS is carried out according to the presenting pathophysiological mechanism. Anti-inflammatory treatment with glucocorticoids is therefore an option. The aim of this study was to systematically review the efficacy of glucocorticoids in CRPS. DATABASES AND DATA TREATMENT: Embase, Medline, Web of Science and Google Scholar were systematically searched for articles focusing on glucocorticoid treatment and CRPS. Screening based on title and abstract was followed by full-text reading (including reference lists) to determine the final set of relevant articles. Bias was assessed using the revised Cochrane risk-of-bias-tool for randomized trials (Rob2).
resultsForty-one studies were included, which reported on 1208 CRPS patients. A wide variety of glucocorticoid administration strategies were applied, with oral being the most frequently chosen. Additionally, researchers found great heterogeneity in outcome parameters, including clinical symptoms, pain relief and range of motion. The use of glucocorticoids caused an improvement of parameters in all but two studies. In particular, improvement in pain relief and range of motion were reported. Using glucocorticoids in CRPS of longer duration (i.e. more than 3 months) appears to be less effective.
conclusionBased on the present review, there is evidence to support glucocorticoid treatment in CRPS. However, the ideal administration route and dose remain unclear. We therefore recommend future research via an intervention study, as well as studies on the aetiological mechanisms and corresponding optimal treatment because CRPS pathogenesis is only partially understood. SIGNIFICANCE: Several studies point towards CRPS being an inflammatory response after tissue or nerve damage, with higher levels of pro-inflammatory cytokines in serum, plasma, cerebrospinal fluid and artificial skin blisters. Inflammation provides a possible role for glucocorticoids in treating CRPS. This systematic review provides a structured overview of glucocorticoid treatment in patients with CRPS. Improvement in pain and range of motion is shown. Systematic review registration number: PROSPERO-CRD42020144671.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.