Evidence map›Paper›PMID 35983963›Full record

ReviewMagnetic resonance in medicine2022

Recent Technical Developments in ASL: A Review of the State of the Art.

Luis Hernandez-Garcia, Verónica Aramendía-Vidaurreta, Divya S Bolar, Weiying Dai, Maria A Fernández-Seara, Jia Guo, Ananth J Madhuranthakam, Henk Mutsaerts, Jan Petr, Qin Qin and 11 more

Abstract readReview
In one paragraph

Review in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Spatially and temporally progressive hypoperfusion in Alzheimer's disease revealed by normative modeling.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Characterizing pre- and post-operative cerebral blood flow and transit time in pediatric moyamoya patients using multi-delay ASL and DSC MRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Luis Hernandez-GarciaFMRI Laboratory, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-3002-0304
Verónica Aramendía-VidaurretaDepartment of Radiology, Clínica Universidad de Navarra, Pamplona, Spain.ORCID 0000-0001-9834-2866
Divya S BolarCenter for Functional Magnetic Resonance Imaging, Department of Radiology, University of California at San Diego, San Diego, California, USA.ORCID 0000-0002-5968-2304
Weiying DaiDepartment of Computer Science, State University of New York at Binghamton, Binghamton, NY, USA.
Maria A Fernández-SearaDepartment of Radiology, Clínica Universidad de Navarra, Pamplona, Spain.ORCID 0000-0001-8536-6295
Jia GuoDepartment of Bioengineering, University of California Riverside, Riverside, California, USA.ORCID 0000-0003-3371-5857
Ananth J MadhuranthakamDepartment of Radiology, UT Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0002-5524-7962
Henk MutsaertsDepartment of Radiology & Nuclear Medicine, Amsterdam University Medical Center, Amsterdam Neuroscience, Amsterdam, The Netherlands.ORCID 0000-0003-0894-0307
Jan PetrHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Dresden, Germany.ORCID 0000-0002-3201-6002
Qin QinThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0002-6432-2944
Jonas SchollenbergerFMRI Laboratory, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-9245-3984
Yuriko SuzukiWellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-4851-7872
Manuel TasoDivision of MRI research, Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-2405-9165
David L ThomasDepartment of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom.ORCID 0000-0003-1491-1641
Matthias J P van OschC.J. Gorter Center for high field MRI, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0001-7034-8959
Joseph WoodsWellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-0329-824X
Moss Y ZhaoDepartment of Radiology, Stanford University, Stanford, California, USA.ORCID 0000-0002-0210-7739
Lirong YanDepartment of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Ze WangDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-8339-5567
Li ZhaoKey Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering & Instrument Science, Zhejiang University, Zhejiang, People's Republic of China.ORCID 0000-0003-4933-3183
Thomas W OkellWellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-8258-0659

Funding

Cerebrovascular Reserve Imaging with Simultaneous PET/MRI Using Arterial Spin Labeling and Deep LearningR01EB025220 · NIBIB · STANFORD UNIVERSITY · PI ZAHARCHUK, GREGORY GEORGE · 2018 to 2021
$2.8M
Novel Ultrasonic Technique for the Treatment of Hemorrhagic StrokeR01NS108042 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PANDEY, ADITYA S · 2018 to 2022
$2.6M
Quantitative MR Imaging of Vascular Factors in Parkinsons DiseaseR01NS112233 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HERNANDEZ-GARCIA, LUIS · 2020 to 2024
$1.8M
Novel Ultrasonic Technique for the Treatment of Hemorrhagic StrokeU01NS108042 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Aditya S Pandey, Zhen Xu · 2025 to 2026
$1.4M
Ultra-fast cerebral blood flow imaging for quantifying brain dynamicsR01EB033210 · NIBIB · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI GUO, JIA · 2022 to 2022
$623k
Quantitative Blood Flow Imaging using Spin Labeled MR FingerprintingR21EB021562 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HERNANDEZ-GARCIA, LUIS · 2016 to 2017
$400k
Development of Layer Specific FMRI for Clinical ScannersR21EB032514 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HERNANDEZ-GARCIA, LUIS · 2023 to 2023
$391k
NIBIB NIH HHS R01 EB025220NIBIB NIH HHS R01 EB033210NIBIB NIH HHS R21 EB021562NIBIB NIH HHS R21 EB032514NINDS NIH HHS R01 NS108042NINDS NIH HHS R01 NS112233NINDS NIH HHS U01 NS108042Wellcome TrustWellcome Trust 203139/Z/16/ZWellcome Trust 220204/Z/20/ZWellcome Trust 539208
6 · The paper itself

Abstract

This review article provides an overview of a range of recent technical developments in advanced arterial spin labeling (ASL) methods that have been developed or adopted by the community since the publication of a previous ASL consensus paper by Alsop et al. It is part of a series of review/recommendation papers from the International Society for Magnetic Resonance in Medicine Perfusion Study Group. Here, we focus on advancements in readouts and trajectories, image reconstruction, noise reduction, partial volume correction, quantification of nonperfusion parameters, fMRI, fingerprinting, vessel selective ASL, angiography, deep learning, and ultrahigh field ASL. We aim to provide a high level of understanding of these new approaches and some guidance for their implementation, with the goal of facilitating the adoption of such advances by research groups and by MRI vendors. Topics outside the scope of this article that are reviewed at length in separate articles include velocity selective ASL, multiple-timepoint ASL, body ASL, and clinical ASL recommendations.

Indexed as

BrainMagnetic Resonance ImagingCerebrovascular CirculationImage Processing, Computer-AssistedMagnetic Resonance AngiographySpin LabelsSpin Labelsarterial spin labelingCBFMR imagingperfusiontechnical advancesvascular imaging

Identifiers

PMID35983963
PMCPMC9420802

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.