ReviewHypertension (Dallas, Tex. : 1979)2022
Gut-Immune-Kidney Axis: Influence of Dietary Protein in Salt-Sensitive Hypertension.
Review in Hypertension (Dallas, Tex. : 1979), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Dietary protein and risk of type 2 diabetes: findings from a registry-based cohort study and a meta-analysis of prospective cohort studies.Nutrition & diabetes · 2025Pooled it
- Gut microbiota-derived polyamine pathways associated with mean blood pressure.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Protective effects of fermentable dietary fiber and propionate in Dahl salt-sensitive hypertension and renal damage.American journal of physiology. Renal physiology · 2026Article
- Organ cross-talk: molecular mechanisms, biological functions, and therapeutic interventions for diseases.Signal transduction and targeted therapy · 2026Review
- The SGK1/ENaC axis in renal injury during salt-sensitive hypertension: from sodium sensing to inflammation.Frontiers in immunology · 2026Review
- Review
- Gut microbiota: an important player in diabetic kidney disease.Diabetology & metabolic syndrome · 2025Review
- Deciphering genetic associations with blood pressure in peripheral blood mononuclear cells through single-cell transcriptomic profiling.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Global Analysis of the Lysine Acetylome in Macrophages from Salt-sensitive Hypertensive Rats.Applied biochemistry and biotechnology · 2025Article
- Modulating the gut-immune axis to alleviate rheumatoid arthritis: mechanistic insights and therapeutic potential of traditional Chinese medicine.Frontiers in immunology · 2025Review
- The evaluation of indoxyl sulfate in the general population in Kanegasaki Iwate: A cross-sectional study (KANEGASAKI study).PloS one · 2025Observational
- Modified Zexie decoction improves phlegm-dampness type stage I hypertension by regulating the gut-immune-kidney axis.Frontiers in pharmacology · 2025Article
- Capsaicin pretreatment attenuates salt-sensitive hypertension by alleviating AMPK/Akt/Nrf2 pathway in hypothalamic paraventricular nucleus.Frontiers in neuroscience · 2024Article
- Bioactive Peptides fromMolecules (Basel, Switzerland) · 2023Article
- Functional NADPH oxidase 2 in T cells amplifies salt-sensitive hypertension and associated renal damage.American journal of physiology. Renal physiology · 2023Article
- Microbiota-associated mechanisms underlying sexual dimorphism in hypertension.Microbiota and host · 2023Article
- Gut microbiota and its metabolites - molecular mechanisms and management strategies in diabetic kidney disease.Frontiers in immunology · 2023Review
- The role and mechanism of gut microbiota-derived short-chain fatty in the prevention and treatment of diabetic kidney disease.Frontiers in immunology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Humans with salt-sensitive hypertension demonstrate increased morbidity, increased mortality, and renal end-organ damage when compared with normotensive subjects or those with salt-resistant hypertension. Substantial evidence from humans and animals has also demonstrated the role of dietary components other than salt to modulate hypertension. Evidence presented in this review provides support for the view that immunity and inflammation serve to amplify the development of salt-sensitive hypertension and leads to malignant disease accompanied by end-organ damage. Interestingly, salt-sensitive disease is modulated by changes in dietary protein intake, which also influences immune mechanisms. Together, the evidence presented in this review from animal and human studies indicates that changes in dietary protein source have profound effects on the gut microbiota, microbiota-derived metabolites, DNA methylation, gene expression, immune cell activation, the production of cytokines and other factors, and the development of salt-sensitive hypertension and related disease phenotypes.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.