ArticleJournal of neuroimaging : official journal of the American Society of Neuroimaging2022
Identification of association fibers using ex vivo diffusion tractography in Alexander disease brains.
Article in Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Imaging of developing human brains with ex vivo PSOCT and dMRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Quantitative diffusion imaging and genotype-by-sex interactions in a rat model of Alexander disease.Magnetic resonance in medicine · 2024Article
- Brain Pathways in LIS1-Associated Lissencephaly Revealed by Diffusion MRI Tractography.Brain sciences · 2023Article
- microRNA Biology on Brain Development and Neuroimaging Approach.Brain sciences · 2022Review
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
background and purposeAlexander disease (AxD) is a neurodegenerative disorder caused by heterozygous Glial Fibrillary Acidic Protein mutation. The characteristic structural findings of AxD, such as leukodystrophic features, are well known, while association fibers of AxD remain uninvestigated. The aim of this study was to explore global and subcortical fibers in four brains with AxD using ex vivo diffusion tractography
methodsHigh-angular-resolution diffusion magnetic resonance imaging (HARDI) tractography and diffusion-tensor imaging (DTI) tractography were used to evaluate long and short association fibers and compared to histological findings in brain specimens obtained from four donors with AxD and two donors without neurological disorders
resultsAxD brains showed impairment of long association fibers, except for the arcuate fasciculus and cingulum bundle, and abnormal trajectories of the inferior longitudinal and fronto-occipital fasciculi on HARDI tractography and loss of multidirectionality in subcortical fibers on DTI tractography. In histological studies, AxD brains showed diffuse low density on Klüver-Barrera and neurofilament staining and sporadic Rosenthal fibers on hematoxylin and eosin staining
conclusionsThis study describes the spatial distribution of degenerations of short and long association fibers in AxD brains using combined tractography and pathological findings.
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