ArticlePlastic and reconstructive surgery. Global open2022
Data-driven Normative Reference of Pediatric Cranial Bone Development.
Article in Plastic and reconstructive surgery. Global open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Unsupervised adaptive sampling graph autoencoder for 3D surface encoding and mesh representation transfer.Medical image analysis · 2026Article
- Data-driven standards for infant skull thickness distributions in computational modeling and analysis.Journal of anatomy · 2025Article
- Imaging Modalities in Craniosynostosis: A Systematic Review and Proposal of the ARCANA Protocol for Multimodal Radiation-Free Assessment.Diagnostics (Basel, Switzerland) · 2025Review
- Population-Driven Synthesis of Personalized Cranial Development From Cross-Sectional Pediatric CT Images.IEEE transactions on bio-medical engineering · 2025Article
- Cranial Bone Changes Associated With Intracranial Hypertension in Apert Syndrome: Insights for Early Surgical Intervention.Plastic and reconstructive surgery. Global open · 2025Article
- Investigation of Cranial Bone Changes Indicative of Increased Intracranial Pressure in Diverse Phenotypes of Craniosynostosis.Plastic and reconstructive surgery. Global open · 2025Article
- SHAPE: A visual computing pipeline for interactive landmarking of 3D photograms and patient reporting for assessing craniosynostosis.Computers & graphics · 2024Article
- Personalized phenotype encoding and prediction of pathological head development from cross-sectional images.... International Symposium on Medical Information Processing and Analysis. International SIPAIM Workshop · 2024Article
- Cranial bone thickness and density anomalies quantified from CT images can identify chronic increased intracranial pressure.Neuroradiology · 2024Article
- Data-driven cranial suture growth model enables predicting phenotypes of craniosynostosis.Scientific reports · 2023Article
- Joint Cranial Bone Labeling and Landmark Detection in Pediatric CT Images Using Context Encoding.IEEE transactions on medical imaging · 2023Article
- Geometric learning and statistical modeling for surgical outcomes evaluation in craniosynostosis using 3D photogrammetry.Computer methods and programs in biomedicine · 2023Article
- Early Outcomes of Endoscopic Spring-Assisted Repair of Metopic Craniosynostosis.The Journal of craniofacial surgeryArticle
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Available normative references of cranial bone development and suture fusion are incomplete or based on simplified assumptions due to the lack of large datasets. We present a fully data-driven normative model that represents the age- and sex-specific variability of bone shape, thickness, and density between birth and 10 years of age at every location of the calvaria. Methods: The model was built using a cross-sectional and multi-institutional pediatric computed tomography image dataset with 2068 subjects without cranial pathology (age 0-10 years). We combined principal component analysis and temporal regression to build a statistical model of cranial bone development at every location of the calvaria. We studied the influences of sex on cranial bone growth, and our bone density model allowed quantifying for the first time suture fusion as a continuous temporal process. We evaluated the predictive accuracy of our model using an independent longitudinal image dataset of 51 subjects. Results: Our model achieved temporal predictive errors of 2.98 ± 0.69 mm, 0.27 ± 0.29 mm, and 76.72 ± 91.50 HU in cranial bone shape, thickness, and mineral density changes, respectively. Significant sex differences were found in intracranial volume and bone surface areas ( Conclusions: We presented the first pediatric age- and sex-specific statistical reference for local cranial bone shape, thickness, and mineral density changes. We showed its predictive accuracy using an independent longitudinal dataset, we studied developmental differences associated with sex, and we quantified suture fusion as a continuous process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.