Evidence map›Paper›PMID 35983429›Full record

Trial reportDrug design, development and therapy2022

Intravenous Lidocaine Significantly Reduces the Propofol Dose in Elderly Patients Undergoing Gastroscopy: A Randomized Controlled Trial.

Song Hu, Mingxia Wang, Siyu Li, Wenyu Zhou, Yi Zhang, Haobing Shi, Pengcheng Ye, Jixiong Sun, Feng Liu, Wei Zhang and 12 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug design, development and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05944887 (Does Intravenous Lidocaine Reduce Propofol Consumption and the Side Effects of Sedation During Gastroscopy in ASA 1 and 2 Patients.), which is not on this map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05944887 nacompletednot on this mapstarted 2023, after this paper: background citation

Does Intravenous Lidocaine Reduce Propofol Consumption and the Side Effects of Sedation During Gastroscopy in ASA 1 and 2 Patients.

TypeinterventionalSponsorErasme University HospitalRan2023 to 2023Enrolled46ConditionsDiagnostic GastroscopyArmsLidocaine 2% Injectable Solution, Saline administration as placebo, Propofol injection, gastroscopy
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 4 institutions in 1 country.

Song Hu *Graduate School, Wannan Medical College, Wuhu, 241002, People's Republic of China.ORCID 0000-0003-0612-0719
Mingxia Wang *Department of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, People's Republic of China.
Siyu Li *Department of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, People's Republic of China.
Wenyu ZhouDepartment of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, People's Republic of China.
Yi ZhangDepartment of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, People's Republic of China.
Haobing ShiDepartment of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, People's Republic of China.
Pengcheng YeDepartment of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, People's Republic of China.
Jixiong SunDepartment of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, People's Republic of China.
Feng LiuDepartment of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, People's Republic of China.
Wei ZhangDepartment of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, People's Republic of China.
Li ZhengDepartment of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, People's Republic of China.
Qianhao HouDepartment of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, People's Republic of China.
Yue WangDepartment of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, People's Republic of China.
Weixin SunDepartment of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, People's Republic of China.
Yuanli ChenDepartment of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, People's Republic of China.
Zhenzhen LuDepartment of Biostatistics, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.
Zhonghua JiDepartment of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, People's Republic of China.ORCID 0000-0002-1257-5448
Lijun LiaoDepartment of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, People's Republic of China.ORCID 0000-0002-3698-5636
Xin LvDepartment of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, People's Republic of China.
Yinglin WangDepartment of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, People's Republic of China.
Xiangrui WangDepartment of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, People's Republic of China.
Hao YangDepartment of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, People's Republic of China.
Shanghai East Hospital · CNTongji University · CNSun Yat-sen University · CNWannan Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Propofol-based sedation has been widely used for gastroscopy, but the risk of respiratory suppression in elderly patients should not be overlooked. Intravenous (IV) lidocaine during surgery can reduce the demand for propofol and the incidence of cardiopulmonary complications. We examined whether IV lidocaine reduces the dose of propofol and the occurrence of adverse events during gastroscopy in elderly patients. Methods: We conducted a prospective, single-center, double-blind randomized controlled trial in elderly patients aged ≥65 years with ASA I-II. Subjects were randomly assigned to the lidocaine group (Group L, n=70), who received IV 1.5 mg kg Results: IV lidocaine reduced the total and maintenance propofol dose in Group L ( Conclusion: IV lidocaine can significantly reduce the amount of propofol, the incidence of hypoxia and postoperative pain during gastroscopy in elderly patients, with a higher patient and gastroscopist satisfaction.

Indexed as

LidocainePropofolAgedAnesthetics, IntravenousAnesthetics, LocalDouble-Blind MethodGastroscopyHumansHypoxiaPostoperative PainProspective StudiesAnesthetics, IntravenousAnesthetics, LocalLidocainePropofolelderly patientgastroscopylidocainepropofolsedation

Identifiers

PMID35983429
PMCPMC9381011
OpenAlexW4291000159

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.