Evidence map›Paper›PMID 35983278›Full record

ReviewACS pharmacology & translational science2022

Recent Advances in Molecular Diagnosis of Pulmonary Fibrosis for Precision Medicine.

Mi Ho Jeong, Hongwei Han, David Lagares, Hyungsoon Im

Open access · greenAbstract readReview
In one paragraph

Review in ACS pharmacology & translational science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Artificial intelligence in respiratory medicine: From diagnosis to treatment and future directions.Chinese medical journal pulmonary and critical care medicine · 2026
    Review
  2. Review
  3. Review
  4. Exosomes fromInternational journal of molecular sciences · 2024
    Article
  5. Chronic Lung and Respiratory Conditions Affecting Lungs and Airways.ACS pharmacology & translational science · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Mi Ho JeongCenter for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, United States.ORCID https://orcid.org/0000-0003-4626-6317
Hongwei HanDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, United States.
David LagaresDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, United States.
Hyungsoon ImCenter for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, United States.ORCID https://orcid.org/0000-0002-0626-1346
Harvard University · USMassachusetts General Hospital · US

Funding

Development of plasmon-enhanced biosensing for multiplexed profiling of extracellular vesiclesR01GM138778 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI IM, HYUNGSOON · 2020 to 2024
$2.3M
Nano-plasmonic technology for high-throughput single exosome analysesR21CA217662 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI IM, HYUNGSOON · 2019 to 2021
$585k
NCI NIH HHS R21 CA217662NIGMS NIH HHS R01 GM138778
6 · The paper itself

Abstract

Pulmonary fibrosis is a serious, progressive lung disease characterized by scarring and stiffening lung tissues, affecting the respiratory system and leading to organ failure. It is a complex disease consisting of alveolar damage, chronic inflammation, and a varying degree of lung fibrosis. Significant challenges with pulmonary fibrosis include the lack of effective means to diagnose the disease at early stages, identify patients at higher risks of progress, and assess disease progression and treatment response. Precision medicine powered by accurate molecular profiling and phenotyping could significantly improve our understanding of the disease's heterogeneity, potential biomarkers for diagnosis and prognosis, and molecular targets for treatment development. This Review discusses various translational model systems, including organoids and lung-on-a-chip systems, biomarkers in single cells and extracellular vesicles, and functional pharmacodynamic markers. We also highlight emerging sensing technologies for molecular characterization of pulmonary fibrosis and biomarker detection.

Identifiers

PMID35983278
PMCPMC9379941
OpenAlexW4286008718

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.