Evidence map›Paper›PMID 35983227›Full record

ArticleFrontiers in neuroscience2022

Development of a composite diffusion tensor imaging score correlating with short-term neurological status in neonatal hypoxic-ischemic encephalopathy.

Kengo Onda, Eva Catenaccio, Jill Chotiyanonta, Raul Chavez-Valdez, Avner Meoded, Bruno P Soares, Aylin Tekes, Harisa Spahic, Sarah C Miller, Sarah-Jane Parker and 7 more

Abstract read
In one paragraph

Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Kengo OndaThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Eva CatenaccioDivision of Pediatric Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Jill ChotiyanontaThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Raul Chavez-ValdezNeuroscience Intensive Care Nursery Program, Division of Neonatology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Avner MeodedEdward B. Singleton Department of Radiology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, United States.
Bruno P SoaresDivision of Neuroradiology, Department of Radiology, Larner College of Medicine at the University of Vermont, Burlington, VT, United States.
Aylin TekesNeuroscience Intensive Care Nursery Program, Division of Neonatology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Harisa SpahicDivision of Neonatology, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Sarah C MillerDivision of Neonatology, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Sarah-Jane ParkerSt. George's University of London, London, United Kingdom.
Charlamaine ParkinsonNeuroscience Intensive Care Nursery Program, Division of Neonatology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Dhananjay M VaidyaDepartment of General Internal Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Ernest M GrahamDivision of Maternal-Fetal Medicine, Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Carl E StafstromNeuroscience Intensive Care Nursery Program, Division of Neonatology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Allen D EverettDivision of Pediatric Cardiology, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Frances J NorthingtonNeuroscience Intensive Care Nursery Program, Division of Neonatology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Kenichi OishiThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Funding

Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in AutismP50HD103538 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Stewart H Mostofsky · 2020 to 2026
$9.9M
Adult Biomarkers in Neonatal Brain Injury and DevelopmentR01HD086058 · NICHD · JOHNS HOPKINS UNIVERSITY · PI EVERETT, ALLEN D, NORTHINGTON, FRANCES J · 2016 to 2020
$3.1M
Advanced therapeutic hypothermia efficacy network modeling in neonatal HIER01HD110091 · NICHD · JOHNS HOPKINS UNIVERSITY · PI EVERETT, ALLEN D, NORTHINGTON, FRANCES J · 2022 to 2025
$2.7M
Development of quantitative MRI DTI analysis tool for preterm neonateR01HD065955 · NICHD · JOHNS HOPKINS UNIVERSITY · PI OISHI, KENICHI · 2011 to 2015
$2.3M
Precision Medicine for Neonatal Hypoxic-Ischemic Encephalopathy: Combined Neuroimaging Clinical Approach to Link Phenotypes to PrognosisR01NS126549 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Kenichi Oishi · 2022 to 2026
$2.0M
Injury of Hippocampal Interneurons following Neonatal Hypoxia-Ischemia and Therapeutic HypothermiaK08NS096115 · NINDS · JOHNS HOPKINS UNIVERSITY · PI CHAVEZ-VALDEZ, RAUL · 2017 to 2021
$1.2M
Cholinergic neuron degeneration after HI: New target for delayed therapy of neonatal HI to improve Learning and Memory DeficitsR21NS123814 · NINDS · JOHNS HOPKINS UNIVERSITY · PI NORTHINGTON, FRANCES J · 2022 to 2023
$450k
NICHD NIH HHS P50 HD103538NICHD NIH HHS R01 HD065955NICHD NIH HHS R01 HD086058NICHD NIH HHS R01 HD110091NINDS NIH HHS K08 NS096115NINDS NIH HHS R01 NS126549NINDS NIH HHS R21 NS123814
6 · The paper itself

Abstract

Hypoxic-ischemic encephalopathy (HIE) is the most common cause of neonatal acquired brain injury. Although conventional MRI may predict neurodevelopmental outcomes, accurate prognostication remains difficult. As diffusion tensor imaging (DTI) may provide an additional diagnostic and prognostic value over conventional MRI, we aimed to develop a composite DTI (cDTI) score to relate to short-term neurological function. Sixty prospective neonates treated with therapeutic hypothermia (TH) for HIE were evaluated with DTI, with a voxel size of 1 × 1 × 2 mm. Fractional anisotropy (FA) and mean diffusivity (MD) from 100 neuroanatomical regions (FA/MD

Indexed as

diffusion tensor imaginghypoxic-ischemic encephalopathyleast absolute shrinkage and selection operatorneonatal brain atlasoutcome predictionserum biomarkersshort-term neurologic outcome

Identifiers

PMID35983227
PMCPMC9379310

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.