Evidence map›Paper›PMID 35983226›Full record

ArticleFrontiers in neuroscience2022

Brainstem activation of GABA

Lorenza Bellusci, Elizabeth Kim, Selena Garcia DuBar, Richard A Gillis, Stefano Vicini, Niaz Sahibzada

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Vagal GABAergic signaling in autonomic control of cardiometabolic function.American journal of physiology. Cell physiology · 2026
    Review
  2. Article
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lorenza BellusciDepartment of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC, United States.
Elizabeth KimDepartment of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC, United States.
Selena Garcia DuBarDepartment of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC, United States.
Richard A GillisDepartment of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC, United States.
Stefano ViciniDepartment of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC, United States.
Niaz SahibzadaDepartment of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC, United States.
Georgetown University · USGeorgetown University Medical Center · US

Funding

GABAergic Interneurons Regulate Brainstem Neural CircuitryR01DK117508 · NIDDK · GEORGETOWN UNIVERSITY · PI VICINI, STEFANO · 2018 to 2021
$1.4M
NIDDK NIH HHS R01 DK117508
6 · The paper itself

Abstract

Background and aim: Local GABAergic signaling in the dorsal vagal complex (DVC) is essential to control gastric function. While the inhibitory GABA Methods: Results: The unilateral microinjection of baclofen into the NTS caused a robust increase in gastric tone and motility that was not affected by ipsilateral vagotomy. Optogenetic activation of SST neurons that followed baclofen effectively suppresses the gastric motility Conclusion: Our results show that GABA

Indexed as

brainstemDMVNTSoptogeneticpatch-clampvagus

Identifiers

PMID35983226
PMCPMC9379309
OpenAlexW4289518573

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.