Evidence map›Paper›PMID 35983053›Full record

ArticleFrontiers in immunology2022

Increased proportion of follicular helper T cells is associated with B cell activation and disease severity in IgA nephropathy.

Wanshan Du, Cai-Yue Gao, Xing You, Liang Li, Zhi-Bin Zhao, Mengting Fang, Zhiming Ye, Meijun Si, Zhe-Xiong Lian, Xueqing Yu

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Wanshan DuSchool of Medicine, South China University of Technology, Guangzhou, China.
Cai-Yue GaoMedical Research Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Xing YouSchool of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou, China.
Liang LiMedical Research Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Zhi-Bin ZhaoMedical Research Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Mengting FangSchool of Medicine, South China University of Technology, Guangzhou, China.
Zhiming YeDepartment of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Meijun SiDepartment of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Zhe-Xiong LianMedical Research Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Xueqing YuSchool of Medicine, South China University of Technology, Guangzhou, China.
Guangdong Academy of Medical Sciences · CNGuangdong Provincial People's Hospital · CNSouth China University of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IgA nephropathy (IgAN) is the most common primary glomerulonephritis, characterized by glomerular deposition of IgA immune complexes, mainly produced by B cells under the regulation of CD4

Indexed as

Glomerulonephritis, IGAHumansLeukocytes, MononuclearSeverity of Illness IndexT Follicular Helper CellsTh17 CellsB cellcell-cell interactionfollicular helper T cellIgA nephropathysingle-cell RNA sequencing

Identifiers

PMID35983053
PMCPMC9381139
OpenAlexW4289524450

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.