Evidence map›Paper›PMID 35983031›Full record

ArticleFrontiers in immunology2022

Gut microbiota in systemic lupus erythematosus patients and lupus mouse model: a cross species comparative analysis for biomarker discovery.

Eya Toumi, Benoit Goutorbe, Anne Plauzolles, Marion Bonnet, Soraya Mezouar, Muriel Militello, Jean-Louis Mege, Laurent Chiche, Philippe Halfon

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Eya ToumiAix-Marseille Univ, Microbes, Evolution, Phylogénie et infection (MEPHI), Institut de recherche pour le développement (IRD), Assistance Publique-Hopitaux de Marseille (APHM), Marseille, France.
Benoit GoutorbeLaboratoire Alphabio, Clinical Research and R&D Department, Marseille, France.
Anne PlauzollesLaboratoire Alphabio, Clinical Research and R&D Department, Marseille, France.
Marion BonnetLaboratoire Alphabio, Clinical Research and R&D Department, Marseille, France.
Soraya MezouarAix-Marseille Univ, Microbes, Evolution, Phylogénie et infection (MEPHI), Institut de recherche pour le développement (IRD), Assistance Publique-Hopitaux de Marseille (APHM), Marseille, France.
Muriel MilitelloAix-Marseille Univ, Microbes, Evolution, Phylogénie et infection (MEPHI), Institut de recherche pour le développement (IRD), Assistance Publique-Hopitaux de Marseille (APHM), Marseille, France.
Jean-Louis MegeAix-Marseille Univ, Microbes, Evolution, Phylogénie et infection (MEPHI), Institut de recherche pour le développement (IRD), Assistance Publique-Hopitaux de Marseille (APHM), Marseille, France.
Laurent ChicheInfectious and Internal Medicine Department, Hôpital Européen Marseille, Marseille, France.
Philippe HalfonAix-Marseille Univ, Microbes, Evolution, Phylogénie et infection (MEPHI), Institut de recherche pour le développement (IRD), Assistance Publique-Hopitaux de Marseille (APHM), Marseille, France.
Alphabio · FRInstitut de Recherche pour le Développement · FRAssistance Publique Hôpitaux de Marseille · FRHôpital Européen · FRMéditerranée Infection Foundation · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An increasing number of studies have provided strong evidence that gut microbiota interact with the immune system and stimulate various mechanisms involved in the pathogenesis of auto-immune diseases such as Systemic Lupus Erythematosus (SLE). Indeed, gut microbiota could be a source of diagnostic and prognostic biomarkers but also hold the promise to discover novel therapeutic strategies. Thus far, specific SLE microbial signatures have not yet been clearly identified with alteration patterns that may vary between human and animal studies. In this study, a comparative analysis of a clinically well-characterized cohort of adult patients with SLE showed reduced biodiversity, a lower

Indexed as

Gastrointestinal MicrobiomeLupus Erythematosus, SystemicAdultAnimalsBacillotaBacteroidetesBiodiversityHumansMicebiomarkersdisease activitydysbiosisgut microbiotahealth careoutcome assessmentsystemic lupus erythematosus

Identifiers

PMID35983031
PMCPMC9378784
OpenAlexW4289519259

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.