Evidence map›Paper›PMID 35982973›Full record

ArticleFrontiers in oncology2022

Whole genome analysis reveals the genomic complexity in metastatic cutaneous squamous cell carcinoma.

Amarinder Singh Thind, Bruce Ashford, Dario Strbenac, Jenny Mitchell, Jenny Lee, Simon A Mueller, Elahe Minaei, Jay R Perry, Sydney Ch'ng, N Gopalakrishna Iyer and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 3 countries.

Amarinder Singh ThindSchool of Medicine, University of Wollongong, Wollongong, NSW, Australia.
Bruce AshfordSchool of Medicine, University of Wollongong, Wollongong, NSW, Australia.
Dario StrbenacSydney Medical School, Faculty of Medicine and Health, The University of Sydney, NSW, Australia.
Jenny MitchellIllawarra Shoalhaven Local Health District, Wollongong, NSW, Australia.
Jenny LeeSydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, NSW, Australia.
Simon A MuellerSydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, NSW, Australia.
Elahe MinaeiIllawarra Health and Medical Research Institute, Wollongong, NSW, Australia.
Jay R PerryIllawarra Health and Medical Research Institute, Wollongong, NSW, Australia.
Sydney Ch'ngSydney Medical School, Faculty of Medicine and Health, The University of Sydney, NSW, Australia.
N Gopalakrishna IyerDepartment of Head and Neck Surgery, National Cancer Center, Singapore, Singapore.
Jonathan R ClarkSydney Medical School, Faculty of Medicine and Health, The University of Sydney, NSW, Australia.
Ruta GuptaAnatomical Pathology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Marie RansonIllawarra Health and Medical Research Institute, Wollongong, NSW, Australia.
University of Wollongong · AUChris O’Brien Lifehouse · AUIllawarra Shoalhaven Local Health District · AUNational Cancer Centre Singapore · SGRoyal Prince Alfred Hospital · AUSydney Local Health District · AUUniversity Hospital of Zurich · CHUniversity of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metastatic cutaneous squamous cell carcinoma (CSCC) is a highly morbid disease requiring radical surgery and adjuvant therapy, which is associated with a poor prognosis. Yet, compared to other advanced malignancies, relatively little is known of the genomic landscape of metastatic CSCC. We have previously reported the mutational signatures and mutational patterns of CCCTC-binding factor (CTCF) regions in metastatic CSCC. However, many other genomic components (indel signatures, non-coding drivers, and structural variants) of metastatic CSCC have not been reported. To this end, we performed whole genome sequencing on lymph node metastases and blood DNA from 25 CSCC patients with regional metastases of the head and neck. We designed a multifaceted computational analysis at the whole genome level to provide a more comprehensive perspective of the genomic landscape of metastatic CSCC. In the non-coding genome, 3' untranslated region (3'UTR) regions of

Indexed as

CSCCcutaneousmetastasesmutationsnoncodingsquamous cell carcinomaUTR - Untranslated regionswhole genome sequencing

Identifiers

PMID35982973
PMCPMC9379253
OpenAlexW4289524804

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.