Evidence map›Paper›PMID 35982753›Full record

ArticleFrontiers in virology (Lausanne, Switzerland)2022

Attenuated HIV-1 Nef But Not Vpu Function in a Cohort of Rwandan Long-Term Survivors.

Gisele Umviligihozo, Jaclyn K Mann, Steven W Jin, Francis M Mwimanzi, Hua-Shiuan A Hsieh, Hanwei Sudderuddin, Guinevere Q Lee, Helen Byakwaga, Conrad Muzoora, Peter W Hunt and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in virology (Lausanne, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 9 institutions in 4 countries.

Gisele UmviligihozoFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.
Jaclyn K MannHIV Pathogenesis Programme, University of KwaZulu-Natal, Durban, South Africa.
Steven W JinFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.
Francis M MwimanziFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.
Hua-Shiuan A HsiehDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.
Hanwei SudderuddinBritish Columbia Centre for Excellence in HIV/AIDS, Vancover, BC, Canada.
Guinevere Q LeeDepartment of Medicine, Weill Cornell Medical College, New York, NY, United States.
Helen ByakwagaDepartment of Community Health, Mbarara University of Science and Technology, Mbarara, Uganda.
Conrad MuzooraDepartment of Medicine, Weill Cornell Medical College, New York, NY, United States.
Peter W HuntDepartment of Community Health, Mbarara University of Science and Technology, Mbarara, Uganda.
Jeff N MartinDepartment of Community Health, Mbarara University of Science and Technology, Mbarara, Uganda.
Jessica E HabererCenter for Global Health, Massachusetts General Hospital, Boston, MA, United States.
Etienne KaritaCentre for Family Health Research, Kigali, Rwanda.
Susan AllenDepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, United States.
Eric HunterDepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, United States.
Zabrina L BrummeFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.
Mark A BrockmanFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.
Simon Fraser University · CACornell University · USMbarara University of Science and Technology · UGAIDS Vancouver · CAEmory National Primate Research CenterEmory University · USHarvard University · USUniversity of California, San Francisco · USUniversity of KwaZulu-Natal · ZA

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MALLORY O JOHNSON · 1988 to 2026
$93.6M
REACH: Research Enterprise to Advance a Cure for HIVUM1AI164565 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Marina Caskey, R. Brad Jones · 2021 to 2026
$32.9M
TB PREVENTION AND HIV IN THE HOMELESS--AN INTERVENTIONR01MH054907 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BANGSBERG, DAVID ROY · 1995 to 2014
$20.7M
NIAID NIH HHS P30 AI027763NIAID NIH HHS UM1 AI164565NIH HHS P51 OD011132NIMH NIH HHS R01 MH054907Wellcome Trust
6 · The paper itself

Abstract

HIV-1 accessory proteins Nef and Vpu enhance viral pathogenesis through partially overlapping immune evasion activities. Attenuated Nef or Vpu functions have been reported in individuals who display slower disease progression, but few studies have assessed the relative impact of these proteins in non-B HIV-1 subtypes or examined paired proteins from the same individuals. Here, we examined the sequence and function of matched Nef and Vpu clones isolated from 29 long-term survivors (LTS) from Rwanda living with HIV-1 subtype A and compared our results to those of 104 Nef and 62 Vpu clones isolated from individuals living with chronic untreated HIV-1 subtype A from the same geographic area.

Indexed as

CD4downregulationHIV non-progressorsHLAimmune evasionpathogenesistetherinviral accessory proteins

Identifiers

PMID35982753
PMCPMC9383652
OpenAlexW4282975403

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.