Evidence map›Paper›PMID 35982735›Full record

ArticleOxidative medicine and cellular longevity2022

Circular RNA hsa_circ_0002360 Promotes Proliferation and Invasion and Inhibits Oxidative Stress in Gastric Cancer by Sponging miR-629-3p and Regulating the PDLIM4 Expression.

Zhengyuan Yu, Jing Lan, Wei Li, Li Jin, Feng Qi, Chen Yu, Hao Zhu

RetractedOpen access · hybridAbstract readRetracted Publication
In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Zhengyuan YuDepartment of Medical Oncology, The First Affiliated Hospital of Soochow University, No. 188, Shizi Street, Gusu District, Suzhou 215006 Jiangsu, China.
Jing LanDepartment of General Surgery, The First Affiliated Hospital of Soochow University, No. 188, Shizi Street, Gusu District, Suzhou 215006 Jiangsu, China.
Wei LiDepartment of Medical Oncology, The First Affiliated Hospital of Soochow University, No. 188, Shizi Street, Gusu District, Suzhou 215006 Jiangsu, China.
Li JinDepartment of Radiotherapy, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, 55# Renmin South Road, 610041 Chengdu, Sichuan, China.
Feng QiDepartment of Pharmacy, The Fourth Affiliated Hospital of Nantong University, Yancheng City No. 1 Peoples' Hospital, Yancheng, 224006 Jiangsu, China.
Chen YuDepartment of Integrated TCM & Western Medicine, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0002-1651-1388
Hao ZhuDepartment of Traditional Chinese Medicine, The First Affiliated Hospital of Soochow University, No. 188, Shizi Street, Gusu District, Suzhou 215006 Jiangsu, China.ORCID https://orcid.org/0000-0003-4138-5624
Soochow University · CNJiangsu Cancer Hospital · CNNantong University · CNUniversity of Electronic Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many studies have found that circRNA hsa_0002360 (circ0002360) plays an important role in cancer onset and progression. However, its role in gastric cancer (GC) remains uncertain. Circ0002360 was found to be upregulated in GC cells using QRT-PCR. Furthermore, miR-629-3p, a target miRNA of circ0002360, was the most suppressed miRNA following circ0002360 overexpression. RNA immunoprecipitation (RIP), dual-luciferase reporter analyses, clone formation, transwell, DCFH-DA, and ELISA assays demonstrated that circ0002360-targeted miR-629-3p promotes cell proliferation and migration while inhibiting oxidative stress. GC-related mRNA microarrays from the GEO and TCGA databases, including GSE103236, GSE79973, GSE33429, GSE22804, GSE84437, and TCGA-STAD datasets, were used to find hub biomarkers between normal and gastric cancer samples. WGCNA and uni-Cox analysis were used to identify 27 survival-related risk genes, which were then used to build a risk model for prognosis prediction. Following that, all patients from the GSE84437 and TCGA-STAD datasets with 27 survival-related genes and enough data on survival status and time were randomly assigned to train (

Indexed as

DNA-Binding ProteinsLIM Domain ProteinsMicroRNAsRNA, CircularStomach NeoplasmsCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansOxidative StressDNA-Binding ProteinsLIM Domain ProteinsMicroRNAsMIRN629 microRNA, humanPDLIM4 protein, humanRNA, Circular

Identifiers

PMID35982735
PMCPMC9381216
OpenAlexW4292432212

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.