ArticleBMC medical imaging2022
3D variable flip angle T1 mapping for differentiating benign and malignant liver lesions at 3T: comparison with diffusion weighted imaging.
Article in BMC medical imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
- Preoperative prediction of meningioma grade based on synthetic MRI quantitative T1 and T2 mapping.Japanese journal of radiology · 2026Article
- Clinical feasibility of accelerated whole liver water TEuropean radiology experimental · 2026Article
- Multiparametric magnetic resonance imaging, diffusion-weighted magnetic resonance imaging, and magnetic resonance elastography: differentiating benign and malignant liver lesions.Diagnostic and interventional radiology (Ankara, Turkey) · 2026Article
- Article
- B1 corrected T1 mapping in the differentiation and prediction of breast cancer.Scientific reports · 2025Article
- Linking elastographic evaluation benign and malignant liver lesion with histopathological data.Bioinformation · 2025Article
- Amide proton transfer-weighted imaging and T1 mapping as diagnostic tools to evaluate high-risk histopathologic phenotypes before surgery in rectal adenocarcinoma and their correlation with Ki-67 expression:a two-center study.Frontiers in oncology · 2025Article
- Positive Correlation between Lipin-1 and Lipin-2 Expressions and Hepatic T1 Values in IUGR Rats.Current medical imaging · 2025Article
- Multiparametric approach with synthetic MR imaging for diagnosing salivary gland lesions.Japanese journal of radiology · 2024Article
- Respiratory motion-corrected T1 mapping of the abdomen.Magma (New York, N.Y.) · 2024Article
- Liver T1 and T2 mapping in a large cohort of healthy subjects: normal ranges and correlation with age and sex.Magma (New York, N.Y.) · 2024Article
- T1 and T2 mapping for identifying malignant lymph nodes in head and neck squamous cell carcinoma.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023Article
- Water-Fat Separated T1 Mapping in the Liver and Correlation to Hepatic Fat Fraction.Diagnostics (Basel, Switzerland) · 2023Article
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Abstract
backgroundDifferent methods have been used to improve the imaging diagnosis of focal liver lesions (FLL). Among them, magnetic resonance imaging (MRI) has received more attention since it provides significant amount of information without radiation exposure. However, atypical imaging characteristics of FLL on MRI may complicate the differential diagnosis between benign and malignant FLL. This study aimed to compare the diagnostic value of T1 mapping and diffusion-weighted imaging (DWI) for differentiating of benign and malignant FLLs.
methodsThis retrospective study enrolled 294 FLLs, including 150 benign and 144 malignant lesions. Whole liver T1 mapping sequences were obtained before and 2 min after the administration of Gd-DTPA to acquire native T1 and enhanced T1 and ΔT1%. Additionally, DWI sequence was conducted to generate apparent diffusion coefficient (ADC) maps. These quantitative parameters were compared using one-way analysis of variance, and the diagnostic accuracy of T1 mapping and ADC for FLLs was calculated by area under the curve (AUC).
resultsSignificant differences were observed regarding the native T1, enhanced T1, ΔT1%, and ADC between benign and malignant FLLs. Furthermore, the sensitivity and specificity of the parameters are as follows: native T1 0.797/0.702 (cut off value 1635.5 ms); enhanced T1, 0.911/0.976 (cutoff value 339.2 ms); ΔT1%, 0.901/0.905 (cutoff value 70.8%); and ADC, 0.975/0.952 (cutoff value 1.21 × 10
conclusionThe 3D Variable flip angle T1 mapping technique with Gd-DTPA has a high clinical potential for identifying benign and malignant FLLs. The enhanced T1 and ΔT1% values have similar diagnostic accuracy compared with DWI in evaluating FLLs. Native T1 shows better performance than DWI in distinguishing benign liver lesions, specifically, cysts, and haemangioma.
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