Evidence map›Paper›PMID 35982275›Full record

ArticleInternational urology and nephrology2022

A novel radical prostatectomy specific index (PSI) for the prediction of major cardiovascular events following surgery.

Christian H Ayoub, Jose M El-Asmar, Nassib F Abou Heidar, Nicolas Najm, Ali A Nasrallah, Hani Tamim, Habib A Dakik, Albert El Hajj

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Article in International urology and nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Christian H AyoubDivision of Urology, Department of Surgery, American University of Beirut Medical Center, Riad El Solh, PO BOX 11-0236, Beirut, 1107 2020, Lebanon.ORCID http://orcid.org/0000-0003-2475-4256
Jose M El-AsmarDivision of Urology, Department of Surgery, American University of Beirut Medical Center, Riad El Solh, PO BOX 11-0236, Beirut, 1107 2020, Lebanon.ORCID http://orcid.org/0000-0001-7749-1045
Nassib F Abou HeidarDivision of Urology, Department of Surgery, American University of Beirut Medical Center, Riad El Solh, PO BOX 11-0236, Beirut, 1107 2020, Lebanon.ORCID http://orcid.org/0000-0003-3811-5543
Nicolas NajmAmerican University of Beirut Medical School, American University of Beirut, Beirut, Lebanon.ORCID http://orcid.org/0000-0002-9500-7840
Ali A NasrallahDepartment of General Surgery, Digestive Diseases and Surgery Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.ORCID http://orcid.org/0000-0001-7086-1410
Hani TamimClinical Research Institute, American University of Beirut, Riad El Solh, PO BOX 11-0236, Beirut, 1107 2020, Lebanon. htamim@aub.edu.lb.ORCID http://orcid.org/0000-0002-6947-7937
Habib A DakikDivision of Cardiology, Department of Internal Medicine, American University of Beirut Medical Center, Riad El Solh, PO BOX 11-0236, Beirut, 1107 2020, Lebanon. hd01@aub.edu.lb.ORCID http://orcid.org/0000-0001-6436-600X
Albert El HajjDivision of Urology, Department of Surgery, American University of Beirut Medical Center, Riad El Solh, PO BOX 11-0236, Beirut, 1107 2020, Lebanon. ae67@aub.edu.lb.ORCID http://orcid.org/0000-0002-0043-7195

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeProstate cancer patients tend to be older with multiple comorbidities and are thus at increased risk for postoperative cardiovascular events after radical prostatectomy (RP). Thus, proper patient selection strategies are essential to decide for or against a surgical approach. We aimed to derive a prostatectomy specific index (PSI) for patients undergoing RP and compare its performance to universally used indices.

methodsThe cohort was derived from National Surgical Quality Improvement Program database between 2005 and 2012. The primary outcome was incidence of major adverse cardiovascular events at 30 days post-surgery including: death, myocardial infarction, or stroke. A multivariable logistic regression model was constructed, performance and calibration were evaluated using a ROC analysis and the Hosmer-Lemeshow test, the PSI index was derived and compared to the RCRI and AUB-HAS2 indices.

resultsA total of 17,299 patients were included in our cohort, with a mean age of 62 ± 7.4 years. Seventy three patients had a cardiac event post RP. The final PSI index encompassed six variables: history of heart disease, age, anemia, American society of anesthesiology class, surgical approach, and hypertension. The PSI ROC analysis provided C-statistic = 0.72, calibration R

conclusionThe PSI model is a procedure tailored index for prediction of major cardiovascular events post RP. It was calibrated using a large national database aiming to optimize treatment selection strategies for prostate cancer patients.

Indexed as

Heart DiseasesProstatic NeoplasmsAgedHumansMaleMiddle AgedProstateProstatectomyRisk AssessmentRisk FactorsCardiac eventProstate cancerRadical prostatectomyRisk indexTreatmentUrology

Identifiers

PMID35982275

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