Evidence map›Paper›PMID 35982253›Full record

ArticleAnalytical and bioanalytical chemistry2022

Neuroprotective activity of selenium nanoparticles against the effect of amino acid enantiomers in Alzheimer's disease.

David Vicente-Zurdo, Sandra Rodríguez-Blázquez, Esther Gómez-Mejía, Noelia Rosales-Conrado, María Eugenia León-González, Yolanda Madrid

Abstract read
PubMed Publisher
In one paragraph

Article in Analytical and bioanalytical chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

David Vicente-ZurdoAnalytical Chemistry Department, Faculty of Chemistry, Complutense University of Madrid, 28040, Madrid, Spain. davidvic@ucm.es.
Sandra Rodríguez-BlázquezAnalytical Chemistry Department, Faculty of Chemistry, Complutense University of Madrid, 28040, Madrid, Spain.
Esther Gómez-MejíaAnalytical Chemistry Department, Faculty of Chemistry, Complutense University of Madrid, 28040, Madrid, Spain.
Noelia Rosales-ConradoAnalytical Chemistry Department, Faculty of Chemistry, Complutense University of Madrid, 28040, Madrid, Spain. nrosales@ucm.es.
María Eugenia León-GonzálezAnalytical Chemistry Department, Faculty of Chemistry, Complutense University of Madrid, 28040, Madrid, Spain.
Yolanda MadridAnalytical Chemistry Department, Faculty of Chemistry, Complutense University of Madrid, 28040, Madrid, Spain.
Universidad Complutense de Madrid · ES

Funding

Comunidad de Madrid PB2018/BAA-4393- AVANSECAL-II-CMComunidad de Madrid S2018/BAA-4393Ministerio de Ciencia e Innovación FPU18/00573Ministerio de Ciencia e Innovación PID2020-114714RB-I00Universidad Complutense de Madrid CT17/17-CT18/17
6 · The paper itself

Abstract

Alzheimer's disease (AD), the most prevalent neurodegenerative disease, is characterized by extracellular accumulation of amyloid-beta protein (Aβ), which is believed to be the very starting event of AD neurodegeneration. In this work, D-Phe, D-Ala, and D-Glu amino acids, which are the non-occurring enantiomeric form in the human body, and also D-Asp and DL-SeMet, have proved to be amyloidogenic regarding Aβ

Indexed as

Alzheimer DiseaseChitosanNanoparticlesNeurodegenerative DiseasesSeleniumAmino AcidsAmyloid beta-PeptidesAntioxidantsHumansPeptide FragmentsStereoisomerismThiobarbituric Acid Reactive SubstancesAmino AcidsAmyloid beta-PeptidesAntioxidantsChitosanPeptide FragmentsSeleniumThiobarbituric Acid Reactive SubstancesAlzheimer’s diseaseAmino acid enantiomersAβ42Experimental designSelenium nanoparticlesTransmission electron microscopy

Identifiers

PMID35982253
OpenAlexW4293068673

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.