Evidence map›Paper›PMID 35982241›Full record

ArticleCommunications biology2022

Metagenomic data from cerebrospinal fluid permits tracing the origin and spread of Neisseria meningitidis CC4821 in China.

Hongbin Chen, Mei Li, Shangyu Tu, Xiaoyang Zhang, Xiaojuan Wang, Yawei Zhang, Chunjiang Zhao, Yinghui Guo, Hui Wang

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Molecular characterization of Neisseria meningitidis isolates from healthy individuals in Meigu County, Sichuan Province, 2021-2024.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  2. Origin ofEmerging microbes & infections · 2025
    Article
  3. Review
  4. Article
  5. Genomic analysis ofNew microbes and new infections · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Hongbin Chen *Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China. chenhongbin_pkuph@163.com.ORCID 0000-0001-5071-2768
Mei Li *Department of Clinical Laboratory, Children's Hospital of Hebei Province, Shijiazhuang, Hebei, China.
Shangyu TuDepartment of Clinical Medicine, Peking University People's Hospital, Peking University Health Science Center, Beijing, China.
Xiaoyang ZhangDepartment of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Xiaojuan WangDepartment of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Yawei ZhangDepartment of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Chunjiang ZhaoDepartment of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Yinghui GuoDepartment of Clinical Laboratory, Children's Hospital of Hebei Province, Shijiazhuang, Hebei, China. HeBeiGyh2021@126.com.
Hui WangDepartment of Clinical Laboratory, Peking University People's Hospital, Beijing, China. whuibj@163.com.ORCID 0000-0001-9220-0357
Peking University · CNHospital of Hebei Province · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metagenomic next-generation sequencing (mNGS) is useful for difficult to cultivate pathogens. Here, we use cerebrospinal fluid mNGS to diagnose invasive meningococcal disease. The complete genome sequences of Neisseria meningitidis were assembled using N. meningitidis of ST4821-serotype C isolated from four patients. To investigate the phylogeny, 165 CC4821 N. meningitidis genomes from 1972 to 2017 were also included. The core genome accumulated variation at a rate of 4.84×10

Indexed as

Meningococcal InfectionsNeisseria meningitidisQuinolonesHumansPhylogenySerogroupQuinolones

Identifiers

PMID35982241
PMCPMC9388655
OpenAlexW4292227836

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.