ArticleEuropean journal of epidemiology2022
The impact of a healthy lifestyle on the risk of esophageal and gastric cancer subtypes.
Article in European journal of epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A Systematic Review and Meta-analysis of the Relationship between Statin Intake and Esophageal Cancer.Anti-cancer agents in medicinal chemistry · 2024Pooled it
- Adherence to the Mediterranean Diet and Risk of Gastric Cancer: A Systematic Review and Meta-Analysis.Nutrients · 2023Pooled it
- How to Keep the Balance between Red and Processed Meat Intake and Physical Activity Regarding Mortality: A Dose-Response Meta-Analysis.Nutrients · 2023Pooled it
- Healthy lifestyle and cancer risk: a pan-cancer analysis in the UK Biobank prospective cohort.British journal of cancer · 2026Article
- Adherence to the Mediterranean diet is associated with reduced risk of head and neck, gastric, and liver cancers: a systematic review and meta-analysis.GeroScience · 2026Article
- Clustering characteristics of upper gastrointestinal cancer risk behaviours and their association with social determinants of health: a latent class analysis.Scientific reports · 2026Article
- Epidemiology of esophageal cancer in Xiamen, China, 2011-2020: trends in incidence, mortality, and survival from a population-based registry study.Cancer causes & control : CCC · 2026Article
- Article
- The effect of cumulative exposure to unhealthy behavioral lifestyles on incident primary dyslipidemia: a prospective study from the Chinese government employee cohort.Lipids in health and disease · 2025Article
- The global, regional, and national burden of early, middle, and late-onset esophageal cancer and trends from 1990 to 2021: a systematic analysis of the Global Burden of Disease Study 2021.Journal of thoracic disease · 2025Article
- Low-dimensional nanomaterials for electrochemical biosensing of gastric cancer biomarkers in whole blood: Current trends and future Prospects.Materials today. Bio · 2025Review
- Spatiotemporal Correlation Analysis for the Incidence of Esophageal and Gastric Cancer From 2010 to 2019: Ecological Study.JMIR cancer · 2025Article
- Long-term trends and projections of stomach cancer burden in China: Insights from the GBD 2021 study.PloS one · 2025Article
- Tetraspanins in digestive‑system cancers: Expression, function and therapeutic potential (Review).Molecular medicine reports · 2024Review
- Association of dietary inflammatory index and dietary oxidative balance score with gastrointestinal cancers in NHANES 2005-2018.BMC public health · 2024Article
- Targeted ferritinophagy in gastrointestinal cancer: from molecular mechanisms to implications.Archives of toxicology · 2024Review
- Causal relationship between gut microbiota and gastric cancer: A two‑sample Mendelian randomization analysis.Molecular and clinical oncology · 2024Article
- Burdens of stomach and esophageal cancer from 1990 to 2019 and projection to 2030 in China: Findings from the 2019 Global Burden of Disease Study.Journal of global health · 2024Article
- The effect of cumulative exposure with unhealthy lifestyles on the H-type hypertension among Chinese adults: a community-based, propensity-score-matched, and case-control study.Frontiers in nutrition · 2024Article
- Review of dietary patterns and gastric cancer risk: epidemiology and biological evidence.Frontiers in oncology · 2024Review
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Abstract
Few prospective studies have been conducted on a combined healthy lifestyle and risk of esophageal and gastric cancer, and even less on subtypes: esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma (EAC), gastric cardia adenocarcinoma (GCA), and gastric non-cardia adenocarcinoma (GNCA). The relationship of a healthy lifestyle score (HLS) with risk of these cancers was investigated in the Netherlands Cohort Study. In 1986, 120,852 men and women aged 55-69 years provided information on dietary and lifestyle habits. The HLS was derived from information on smoking, body mass index, physical activity, Mediterranean diet adherence, and alcohol intake. After 20.3 years of follow-up, multivariable case-cohort analyses were based on 333 incident esophageal and 777 gastric cancer cases, and 3720 subcohort members with complete data on lifestyles and confounders. The impact of changing to healthy lifestyles was estimated with the rate advancement period (RAP). The HLS was significantly inversely associated with risk of esophageal and gastric cancer, and subtypes (except EAC), in a linear fashion. The observed HR decrease per 1-point increase in HLS was 31% for esophageal, and 19% for gastric cancer, 49% for ESCC, 23% for GCA, and 18% for GNCA. The RAP per 1-point increase in HLS ranged from - 11.75 years for ESCC to - 2.85 years for GNCA. Also after excluding smoking, inverse associations between the HLS and esophageal and gastric cancer risk were still apparent. These results suggest that adhering to a combination of healthy modifiable lifestyle factors may substantially reduce the risk of esophageal and gastric cancer.
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