Evidence map›Paper›PMID 35982075›Full record

ArticleNature communications2022

Chemical zymogens for the protein cysteinome.

Mireia Casanovas Montasell, Pere Monge, Sheiliza Carmali, Livia Mesquita Dias Loiola, Dante Guldbrandsen Andersen, Kaja Borup Løvschall, Ane Bretschneider Søgaard, Maria Merrild Kristensen, Jean Maurice Pütz, Alexander N Zelikin

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Dynamic Transcription Machineries in Protocells.Journal of the American Chemical Society · 2025
    Review
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  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Mireia Casanovas MontasellDepartment of Chemistry, Aarhus University, 8000, Aarhus, Denmark.ORCID 0000-0002-5472-3015
Pere MongeDepartment of Chemistry, Aarhus University, 8000, Aarhus, Denmark.
Sheiliza CarmaliDepartment of Chemistry, Aarhus University, 8000, Aarhus, Denmark.ORCID 0000-0003-3436-4745
Livia Mesquita Dias LoiolaDepartment of Chemistry, Aarhus University, 8000, Aarhus, Denmark.
Dante Guldbrandsen AndersenDepartment of Chemistry, Aarhus University, 8000, Aarhus, Denmark.
Kaja Borup LøvschallDepartment of Chemistry, Aarhus University, 8000, Aarhus, Denmark.
Ane Bretschneider SøgaardDepartment of Chemistry, Aarhus University, 8000, Aarhus, Denmark.
Maria Merrild KristensenDepartment of Chemistry, Aarhus University, 8000, Aarhus, Denmark.
Jean Maurice PützDepartment of Chemistry, Aarhus University, 8000, Aarhus, Denmark.
Alexander N ZelikinDepartment of Chemistry, Aarhus University, 8000, Aarhus, Denmark. zelikin@chem.au.dk.ORCID 0000-0002-9864-321X
Aarhus University · DKQueen's University Belfast · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present three classes of chemical zymogens established around the protein cysteinome. In each case, the cysteine thiol group was converted into a mixed disulfide: with a small molecule, a non-degradable polymer, or with a fast-depolymerizing fuse polymer (Z

Indexed as

CysteineEnzyme PrecursorsDisulfidesPolymersCysteineDisulfidesEnzyme PrecursorsPolymers

Identifiers

PMID35982075
PMCPMC9388531
OpenAlexW4292679994

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.