Evidence map›Paper›PMID 35981745›Full record

ArticleThe European respiratory journal2023

COVID-19 infection and its impact on case fatality in patients with pulmonary embolism.

Lukas Hobohm, Ingo Sagoschen, Stefano Barco, Ioannis T Farmakis, Ugo Fedeli, Sebastian Koelmel, Tommaso Gori, Christine Espinola-Klein, Thomas Münzel, Stavros Konstantinides and 1 more

Open access · hybridAbstract read
In one paragraph

Article in The European respiratory journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
8.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Drivers and recent trends of hospitalisation costs related to acute pulmonary embolism.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
    Article
  5. Article
  6. Time trends of catheter-directed treatment in acute pulmonary embolism in Germany.Research and practice in thrombosis and haemostasis · 2025
    Article
  7. Article
  8. Article
  9. Pathogenic mechanisms of cardiovascular damage in COVID-19.Molecular medicine (Cambridge, Mass.) · 2024
    Review
  10. Predicting Acute Cardiovascular Complications in COVID-19: Insights from a Specialized Cardiac Referral Department.Medical science monitor : international medical journal of experimental and clinical research · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. [Pulmonary embolism].Zeitschrift fur Herz-, Thorax- und Gefasschirurgie · 2023
    Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Lukas HobohmDepartment of Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany lukas.hobohm@unimedizin-mainz.de.ORCID 0000-0002-4312-0366
Ingo SagoschenDepartment of Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Stefano BarcoCenter for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.ORCID 0000-0002-2618-347X
Ioannis T FarmakisCenter for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.ORCID 0000-0002-0586-6386
Ugo FedeliEpidemiological Department, Azienda Zero, Padova, Italy.
Sebastian KoelmelDepartment of Internal Medicine, Triemli Hospital Zurich, Zurich, Switzerland.
Tommaso GoriDepartment of Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Christine Espinola-KleinDepartment of Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Thomas MünzelDepartment of Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Stavros KonstantinidesCenter for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.ORCID 0000-0001-6359-7279
Karsten KellerDepartment of Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.ORCID 0000-0002-0820-9584
Johannes Gutenberg University Mainz · DEDemocritus University of Thrace · GRTriemli Hospital · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough a high prevalence of pulmonary embolism (PE) has been reported in association with coronavirus disease 2019 (COVID-19) in critically ill patients, nationwide data on the outcome of hospitalised patients with COVID-19 and PE are still limited. Thus, we investigated seasonal trends and predictors of in-hospital death in patients with COVID-19 and PE in Germany.

methodsWe used a German nationwide inpatient sample to analyse data on hospitalisations among COVID-19 patients with and without PE during 2020, and to detect changes in PE prevalence and case fatality in comparison with 2019.

resultsWe analysed 176 137 COVID-19 hospitalisations in 2020; PE was recorded in 1.9% (n=3362) of discharge certificates. Almost one-third of patients with COVID-19 and PE died during the in-hospital course (28.7%) compared with COVID-19 patients without PE (17.7%). Between 2019 and 2020, numbers of PE-related hospitalisations were largely unchanged (98 485

conclusionsIn Germany, the prevalence of PE events during hospitalisations was similar in 2019 and 2020. However, the fatality rate among patients with both COVID-19 and PE was substantially higher than that in those with only one of these diseases, suggesting a life-threatening additive prognostic impact of the COVID-19-PE combination.

Indexed as

COVID-19Pulmonary EmbolismHospital MortalityHumansInpatientsPrognosis

Identifiers

PMID35981745
PMCPMC9411730
OpenAlexW4292213001

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.