Evidence map›Paper›PMID 35981243›Full record

ArticleJournal of proteome research2022

Glycoproteomics Identifies Plexin-B3 as a Targetable Cell Surface Protein Required for the Growth and Invasion of Triple-Negative Breast Cancer Cells.

Laura Kuhlmann, Meinusha Govindarajan, Salvador Mejia-Guerrero, Vladimir Ignatchenko, Lydia Y Liu, Barbara T Grünwald, Jennifer Cruickshank, Hal Berman, Rama Khokha, Thomas Kislinger

Open access · bronzeAbstract read
In one paragraph

Article in Journal of proteome research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

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  10. An X-linkedTranslational pediatrics · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Laura KuhlmannPrincess Margaret Cancer Center, University Health Network, Toronto, Ontario M5G 1L7, Canada.
Meinusha GovindarajanPrincess Margaret Cancer Center, University Health Network, Toronto, Ontario M5G 1L7, Canada.
Salvador Mejia-GuerreroPrincess Margaret Cancer Center, University Health Network, Toronto, Ontario M5G 1L7, Canada.
Vladimir IgnatchenkoPrincess Margaret Cancer Center, University Health Network, Toronto, Ontario M5G 1L7, Canada.
Lydia Y LiuPrincess Margaret Cancer Center, University Health Network, Toronto, Ontario M5G 1L7, Canada.ORCID 0000-0001-6026-3169
Barbara T GrünwaldPrincess Margaret Cancer Center, University Health Network, Toronto, Ontario M5G 1L7, Canada.
Jennifer CruickshankPrincess Margaret Cancer Center, University Health Network, Toronto, Ontario M5G 1L7, Canada.
Hal BermanPrincess Margaret Cancer Center, University Health Network, Toronto, Ontario M5G 1L7, Canada.
Rama KhokhaPrincess Margaret Cancer Center, University Health Network, Toronto, Ontario M5G 1L7, Canada.
Thomas KislingerPrincess Margaret Cancer Center, University Health Network, Toronto, Ontario M5G 1L7, Canada.ORCID 0000-0003-3525-5540
University Health Network · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Driven by the lack of targeted therapies, triple-negative breast cancers (TNBCs) have the worst overall survival of all breast cancer subtypes. Considering that cell surface proteins are favorable drug targets and are predominantly glycosylated, glycoproteome profiling has significant potential to facilitate the identification of much-needed drug targets for TNBCs. Here, we performed

Indexed as

Triple Negative Breast NeoplasmsCell Adhesion MoleculesCell Line, TumorCell ProliferationHumansMembrane ProteinsNerve Tissue ProteinsNeural Cell Adhesion MoleculesCell Adhesion MoleculesMembrane ProteinsNerve Tissue ProteinsNeural Cell Adhesion MoleculesplexinPLXNB3 protein, humancell surface targetsCRISPR-Cas9glycoproteomicsspheroidstriple-negative breast cancerxenograft

Identifiers

PMID35981243
PMCPMC9442790
OpenAlexW4292227900

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.