ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2023
Plasma Biomarkers of Alzheimer's Disease Are Associated with Physical Functioning Outcomes Among Cognitively Normal Adults in the Multiethnic HABS-HD Cohort.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Motor performance and its association with Alzheimer's-related biomarkers: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Pooled it
- Effects of a 2-year exercise training on neuromuscular system health in older individuals with low muscle function.Journal of cachexia, sarcopenia and muscle · 2023Trial
- Alzheimer's disease biomarkers in relation to non-cognitive domains within the intrinsic capacity framework: a narrative review.GeroScience · 2026Review
- Contextualizing Blood-Based Biomarkers for Dementia Globally.Journal of neurochemistry · 2026Review
- Contrasting associations of diastolic blood pressure with plasma amyloid, tau, and neurodegeneration biomarkers in the Health and Aging Brain Study-Health Disparities (HABS-HD).Journal of Alzheimer's disease : JAD · 2026Article
- Evaluation of a panel of plasma biomarkers for Alzheimer's disease in a diverse research cohort.Journal of Alzheimer's disease : JAD · 2026Article
- Discussing the Interplay of Social Determinants of Health, Aging, and Alzheimer's Biomarkers in U.S. Latinos.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Review
- Relationship of Alzheimer's Disease and Related Dementias Plasma Biomarkers With Mobility in Cognitively Unimpaired Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Chronic stress, social support, and Alzheimer's blood-based biomarkers in the HABS-HD study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Alzheimer's disease plasma biomarkers and physical functioning in a diverse sample of adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Meaning in life and neurobiomarkers of brain health in the UK Biobank.Journal of Alzheimer's disease : JAD · 2025Article
- Neurofilament light and cognition in community-dwelling non-Hispanic Blacks.Journal of Alzheimer's disease : JAD · 2024Article
- Associations Between Blood-Based Biomarkers and Cognitive and Functional Trajectories Among Participants of the MEMENTO Cohort.Neurology · 2024Article
- Demographic and Clinical Characteristics Associated With Serum GFAP Levels in an Ethnically Diverse Cohort.Neurology · 2023Article
- Comorbidities Incorporated to Improve Prediction for Prevalent Mild Cognitive Impairment and Alzheimer's Disease in the HABS-HD Study.Journal of Alzheimer's disease : JAD · 2023Article
- Combination of Serum and Plasma Biomarkers Could Improve Prediction Performance for Alzheimer's Disease.Genes · 2022Article
- Associations of plasma p-Tau217 with cognitive domain performance in clinically unimpaired participants: Evidence from HABS-HD.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
In this study, we examined the link between plasma Alzheimer's disease (AD) biomarkers and physical functioning outcomes within a community-dwelling, multiethnic cohort. Data from 1 328 cognitively unimpaired participants (n = 659 Mexican American and n = 669 non-Hispanic White) from the ongoing Health & Aging Brain Study-Health Disparities (HABS-HD) cohort were examined. Plasma AD biomarkers (amyloid beta [Aβ]40, Aβ42, total tau [t-tau], and neurofilament light chain [NfL]) were assayed using the ultra-sensitive Simoa platform. Physical functioning measures were the Timed Up and Go (TUG) and the Short Physical Performance Battery (SPPB). Cross-sectional linear regression analyses revealed that plasma Aβ 40 (p < .001), Aβ 42 (p = .003), and NfL (p < .001) were each significantly associated with TUG time in seconds. Plasma Aβ 40 (p < .001), Aβ 42 (p < .001), t-tau (p = .002), and NfL (p < .001) were each significantly associated with SPPB Total Score. Additional analyses demonstrate that the link between plasma AD biomarkers and physical functioning outcomes were strongest among Mexican Americans. Plasma AD biomarkers are receiving a great deal of attention in the literature and are now available clinically including use in clinical trials. The examination of AD biomarkers and physical functioning may allow for the development of risk profiles, which could stratify a person's risk for neurodegenerative diseases, such as AD, based on plasma AD biomarkers, physical functioning, ethnicity, or a combination of these measures prior to the onset of cognitive impairment.
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Registered trials
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