Evidence map›Paper›PMID 35980285›Full record

ReviewGenesis (New York, N.Y. : 2000)2022

Advances and challenges in intravital imaging of craniofacial and dental progenitor cells.

Dongwook Yang, Laura Ortinau, Youngjae Jeong, Dongsu Park

Open access · greenAbstract readReview
In one paragraph

Review in Genesis (New York, N.Y. : 2000), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Dongwook YangDepartment of Molecular & Human Genetics, Baylor College of Medicine, Houston, Texas, USA.
Laura OrtinauDepartment of Molecular & Human Genetics, Baylor College of Medicine, Houston, Texas, USA.
Youngjae JeongDepartment of Molecular & Human Genetics, Baylor College of Medicine, Houston, Texas, USA.
Dongsu ParkDepartment of Molecular & Human Genetics, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-2570-3250
Baylor College of Medicine · US

Funding

Hematology Training ProgramT32DK060445 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI GOODELL, MARGARET A. · 2002 to 2023
$8.3M
Regulation of Skeletal progenitor cells in Osteogenesis ImperfectaR01DE031288 · NIDCR · BAYLOR COLLEGE OF MEDICINE · PI Brendan Lee, Dongsu Park · 2022 to 2026
$3.3M
Defining periosteal skeletal stem cells and novel migration mechanisms in bone regeneration and repair in vivoR01AR072018 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI PARK, DONGSU · 2018 to 2023
$2.1M
A new model for spatio-temporal coupling of bone formation and bone resorption governed by osteoclastsR61AR078073 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MISHINA, YUJI, PARK, DONGSU · 2020 to 2021
$694k
A new model for spatio-temporal coupling of bone formation and bone resorption governed by osteoclastsR33AR078073 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MISHINA, YUJI, PARK, DONGSU · 2023 to 2023
$393k
Diffuse microdamage in bone: Direct repair without remodelingR21AR060445 · NIAMS · CITY COLLEGE OF NEW YORK · PI SCHAFFLER, MITCHELL B · 2011 to 2012
$371k
NIAMS NIH HHS R01 AR072018NIAMS NIH HHS R01AR072018NIAMS NIH HHS R33 AR078073NIAMS NIH HHS R61 AR078073NIAMS NIH HHS R61AR078073NIAMS NIH HHS T32DK060445NIDCR NIH HHS R01 DE031288NIDDK NIH HHS T32 DK060445
6 · The paper itself

Abstract

Craniofacial and appendicular bone homeostasis is dynamically regulated by a balance between bone formation and resorption by osteoblasts and osteoclasts, respectively. Despite the developments in multiple imaging techniques in bone biology, there are still technical challenges and limitations in the investigation of spatial/anatomical location of rare stem/progenitor cells and their molecular regulation in tooth and craniofacial bones of living animals. Recent advances in live animal imaging techniques for the craniofacial and dental apparatus can provide new insights in real time into bone stem/progenitor cell dynamics and function in vivo. Here, we review the current inventions and applications of the noninvasive intravital imaging technique and its practical uses and limitations in the analysis of stem/progenitor cells in craniofacial and dental apparatus in vivo. Furthermore, we also explore the potential applications of intravital microscopy in the dental field.

Indexed as

Bone and BonesMolecular ImagingAnimalsIntravital MicroscopyOsteoclastsStem Cellscalvarial bonedental apparatusintravital imagingskeletal stem cells

Identifiers

PMID35980285
PMCPMC10015615
OpenAlexW4292202557

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.