SynthesisTransplant infectious disease : an official journal of the Transplantation Society2022
Neuroinvasive West Nile virus infections after solid organ transplantation: Single center experience and systematic review.
Synthesis in Transplant infectious disease : an official journal of the Transplantation Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Neuroinvasive West Nile virus infections after solid organ transplantation: Single center experience and systematic review.Transplant infectious disease : an official journal of the Transplantation Society · 2022Pooled it
- West Nile virus encephalitis in a kidney transplant recipient: a case report and review of the literature.Clinical transplantation and research · 2026Article
- Donor-Derived West Nile Virus Infection in Kidney Transplant Recipients, France, 2025.Emerging infectious diseases · 2026Article
- West Nile virus neuroinvasive disease and cardiac involvement in critically ill patients in central Italy: a case series.Frontiers in medicine · 2026Article
- Extrapolation and comparison of West Nile virus- and Usutu virus-associated neurological diseases in humans: linking pathology to clinical symptoms.Clinical microbiology reviews · 2025Review
- Reprogramming of liver metabolism during West Nile virus infection unveils novel aspects of disease pathophysiology.Molecular medicine (Cambridge, Mass.) · 2025Article
- Updates on Donor-Derived Infection in Solid Organ Transplantation, Report from the 2024 GTI (Infection and Transplantation Group) Annual Meeting.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- A Scoping Review of Arthropod-Borne Flavivirus Infections in Solid Organ Transplant Recipients.Transplant infectious disease : an official journal of the Transplantation Society · 2024Article
- Review
- Perspective on donor-derived infections in Italy.Transplant infectious disease : an official journal of the Transplantation Society · 2024Review
- Clinical and Diagnostic Features of West Nile Virus Neuroinvasive Disease in New York City.Pathogens (Basel, Switzerland) · 2024Article
- Identifying CNS infections in transplantation and immunomodulatory therapy.Therapeutic advances in infectious diseaseReview
- Catastrophic Case of West Nile Virus Rhombencephalitis in AIDS.Journal of investigative medicine high impact case reportsArticle
- West Nile virus seropositivity in Alanya, a coastal city in the Mediterranean region of Turkey.Annals of Saudi medicineArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
West Nile virus (WNv) is a major cause of viral encephalitis in the United States. WNv infection is usually asymptomatic or a limited febrile illness in the immunocompetent hosts, although a small percentage can develop neuroinvasive disease. Neuroinvasive disease due to WNv in solid organ transplant recipients occurs at higher rates than observed in the general population and can have long term neurological sequalae.
methodsWe retrospectively reviewed medical records of all solid organ transplant recipients at our institution who tested positive for WNv from 2010 to 2018. Two reviewers performed electronic searches of Medline, Embase, Cochrane Library of literature of WNv infections in SOT. Descriptive statistics were performed on key variables.
resultsEight recipients (mean age 54, five males) were diagnosed with neuroinvasive WNv infection at our institution. Distribution of infection was as follows: five kidney transplants, one in each kidney-pancreas, liver, and lung. Diagnoses included meningitis (3), encephalitis (1), meningo-encephalitis (4). Median time from transplant to infection was 49.8 months (2.7-175.4). No infections were considered donor-derived. Five patients received treatment with IVIG. Six patients were alive at median follow-up of 49.5 months (21.7-116.8). We identified 29 studies published from 2002 to 2019. Median time from transplant to infection was 14.2 months, with similar allograft distribution; 53% were donor-derived infections.
conclusionWNv infections in solid organ transplant recipients can be a consequence of organ donation or can be acquired via the community. Infections can be more severe in SOT recipients and lead to neuroinvasive disease.
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