Evidence map›Paper›PMID 35980204›Full record

ArticleMicrobiology spectrum2022

Monitoring SARS-CoV-2 Infection Using a Double Reporter-Expressing Virus.

Kevin Chiem, Jun-Gyu Park, Desarey Morales Vasquez, Richard K Plemper, Jordi B Torrelles, James J Kobie, Mark R Walter, Chengjin Ye, Luis Martinez-Sobrido

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  7. A bireporter recombinant SARS-CoV-2 Omicron BA.5 forbioRxiv : the preprint server for biology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Kevin ChiemTexas Biomedical Research Institutegrid.250889.e, San Antonio, Texas, USA.
Jun-Gyu ParkTexas Biomedical Research Institutegrid.250889.e, San Antonio, Texas, USA.
Desarey Morales VasquezTexas Biomedical Research Institutegrid.250889.e, San Antonio, Texas, USA.
Richard K PlemperCenter for Translational Antiviral Research, Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia, USA.
Jordi B TorrellesTexas Biomedical Research Institutegrid.250889.e, San Antonio, Texas, USA.
James J KobieDepartment of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Mark R WalterDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Chengjin YeTexas Biomedical Research Institutegrid.250889.e, San Antonio, Texas, USA.ORCID 0000-0002-1934-9494
Luis Martinez-SobridoTexas Biomedical Research Institutegrid.250889.e, San Antonio, Texas, USA.ORCID 0000-0001-7084-0804
Texas Biomedical Research Institute · USUniversity of Alabama at Birmingham · USGeorgia State University · US

Funding

NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00014 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GARCIA-SASTRE, ADOLFO · 2021 to 2025
$62.6M
Development of a Broad-Spectrum Inhibitor against Seasonal and Highly-Pathogenic Influenza VirusesR01AI141222 · NIAID · GEORGIA STATE UNIVERSITY · PI PLEMPER, RICHARD K. · 2019 to 2023
$5.0M
Development of a High-Throughput Microfluidics-Enabled Functional Assay for Rapidly Identifying Neutralizing AntibodiesR01AI141607 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI DE FIGUEIREDO, PAUL, HAN, ARUM · 2019 to 2023
$3.4M
Mechanism-based Targeting of the RNA Processing Machinery of SARS-CoV-2R01AI161363 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI GUPTA, YOGESH K · 2021 to 2025
$3.2M
Dynamics of the protective vaccine-induced human influenza neuraminidase B cell responseR01AI145332 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KOBIE, JAMES J, MARTINEZ-SOBRIDO, LUIS · 2019 to 2022
$3.0M
The origin and future protective activity of SARS-CoV-2 RBD specific neutralizing antibodiesR01AI161175 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KOBIE, JAMES J, MARTINEZ-SOBRIDO, LUIS · 2021 to 2024
$2.5M
Roles of the Nucleoprotein 3'-5' Exonuclease Domain in Arenavirus BiologyR01AI142985 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI DE LA TORRE, JUAN C., MARTINEZ-SOBRIDO, LUIS · 2019 to 2022
$1.8M
Developing a Thermostable SARS-CoV-2 RBD-particle VaccineR43AI165089 · NIAID · POP BIOTECHNOLOGIES, INC · PI HUANG, WEI-CHIAO · 2021 to 2022
$600k
NIAID NIH HHS 75N93021C00014NIAID NIH HHS R01 AI141222NIAID NIH HHS R01 AI141607NIAID NIH HHS R01 AI142985NIAID NIH HHS R01 AI145332NIAID NIH HHS R01 AI161175NIAID NIH HHS R01 AI161363NIAID NIH HHS R43 AI165089
6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the highly contagious agent responsible for the coronavirus disease 2019 (COVID-19) pandemic. An essential requirement for understanding SARS-CoV-2 biology and the impact of antiviral therapeutics is a robust method to detect the presence of the virus in infected cells or animal models. Despite the development and successful generation of recombinant (r)SARS-CoV-2-expressing fluorescent or luciferase reporter genes, knowledge acquired from their use in

Indexed as

COVID-19Angiotensin-Converting Enzyme 2AnimalsAntibodies, NeutralizingAntiviral AgentsCricetinaeHumansLuciferasesMiceMice, TransgenicSARS-CoV-2Virus ReplicationAngiotensin-Converting Enzyme 2Antibodies, NeutralizingAntiviral AgentsLuciferasescoronavirusfluorescentinfectionluciferaserecombinantreporterSARS-CoV-2transmission

Identifiers

PMID35980204
PMCPMC9603146
OpenAlexW4292202473

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.