Evidence map›Paper›PMID 35980186›Full record

ArticleMicrobiology spectrum2022

Tumor Progression Locus 2 Protects against Acute Respiratory Distress Syndrome in Influenza A Virus-Infected Mice.

Krishna Latha, Sanjana Rao, Kaori Sakamoto, Wendy T Watford

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Krishna LathaDepartment of Infectious Diseases, University of Georgiagrid.213876.9, Athens, Georgia, USA.ORCID 0000-0001-6496-1159
Sanjana RaoDepartment of Genetics, University of Georgiagrid.213876.9, Athens, Georgia, USA.
Kaori SakamotoDepartment of Pathology, University of Georgiagrid.213876.9, Athens, Georgia, USA.
Wendy T WatfordDepartment of Infectious Diseases, University of Georgiagrid.213876.9, Athens, Georgia, USA.ORCID 0000-0003-4261-5399
University of Georgia · US

Funding

Regulation of mucosal immunity to respiratory viruses by Tpl2R21AI147003 · NIAID · UNIVERSITY OF GEORGIA · PI WATFORD, WENDY T · 2019 to 2020
$415k
NIAID NIH HHS R21 AI147003
6 · The paper itself

Abstract

Excessive inflammation in patients with severe influenza disease may lead to acute lung injury that results in acute respiratory distress syndrome (ARDS). ARDS is associated with alveolar damage and pulmonary edema that severely impair gas exchange, leading to hypoxia. With no existing FDA-approved treatment for ARDS, it is important to understand the factors that lead to virus-induced ARDS development to improve prevention, diagnosis, and treatment. We have previously shown that mice deficient in the serine-threonine mitogen-activated protein kinase, Tpl2 (MAP3K8 or COT), succumb to infection with a typically low-pathogenicity strain of influenza A virus (IAV; HKX31, H3N2 [x31]). The goal of the current study was to evaluate influenza A virus-infected

Indexed as

Influenza A virusMAP Kinase Kinase KinasesNeoplasmsOrthomyxoviridae InfectionsRespiratory Distress SyndromeAnimalsHumansInfluenza A Virus, H3N2 SubtypeLactate DehydrogenasesMiceProtein Serine-Threonine KinasesProto-Oncogene ProteinsLactate DehydrogenasesMap3k8 protein, mouseMAP Kinase Kinase KinasesProtein Serine-Threonine KinasesProto-Oncogene ProteinsARDSbiomarkersedemainfluenzaTpl2

Identifiers

PMID35980186
PMCPMC9604045
OpenAlexW4292202476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.