Evidence map›Paper›PMID 35980113›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2022

Anti-cancer and immunomodulatory evaluation of new nicotinamide derivatives as potential VEGFR-2 inhibitors and apoptosis inducers:

Reda G Yousef, Alaa Elwan, Ibraheem M M Gobaara, Ahmed B M Mehany, Wagdy M Eldehna, Souad A El-Metwally, Bshra A Alsfouk, Eslam B Elkaeed, Ahmed M Metwaly, Ibrahim H Eissa

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 42 citations in OpenAlex.

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  11. Computer-assisted drug discovery (CADD) of an anti-cancer derivative of the theobromine alkaloid inhibiting VEGFR-2.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 6 countries.

Reda G YousefPharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Alaa ElwanPharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Ibraheem M M GobaaraZoology Department, Faculty of Science (Boys), Al-Azhar University, Cairo, Egypt.
Ahmed B M MehanyZoology Department, Faculty of Science (Boys), Al-Azhar University, Cairo, Egypt.
Wagdy M EldehnaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.
Souad A El-MetwallyDepartment of Basic Science, Higher Technological institute, 10th of Ramadan City, Egypt.
Bshra A AlsfoukDepartment of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
Eslam B ElkaeedDepartment of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh, Saudi Arabia.
Ahmed M MetwalyPharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Ibrahim H EissaPharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.ORCID 0000-0002-6955-2263
Al-Azhar University · EGAlfaisal University · SAHigher Technological Institute · EGKafrelsheikh University · EGPrincess Nourah bint Abdulrahman University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

New nicotinamide derivatives

Indexed as

Antineoplastic AgentsVascular Endothelial Growth Factor Receptor-2ApoptosisCell ProliferationDrug DesignDrug Screening Assays, AntitumorMolecular Docking SimulationMolecular StructureNiacinamideProtein Kinase InhibitorsStructure-Activity RelationshipAntineoplastic AgentsNiacinamideProtein Kinase InhibitorsVascular Endothelial Growth Factor Receptor-2Anticancerapoptosiscell cycleimmunomodulatorynicotinamideVEGFR-2 inhibition

Identifiers

PMID35980113
PMCPMC9466619
OpenAlexW4293826815

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.