ArticleAmerican journal of physiology. Renal physiology2022
The lonidamine derivative H2-gamendazole reduces cyst formation in polycystic kidney disease.
Shirin V Sundar, Julie Xia Zhou, Brenda S Magenheimer, Gail A Reif, Darren P Wallace, Gunda I Georg, Sudhakar R Jakkaraj, Joseph S Tash, Alan S L Yu, Xiaogang Li and 1 more
Article in American journal of physiology. Renal physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
Shirin V SundarDepartment of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas.
Julie Xia ZhouJared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas.
Brenda S MagenheimerDepartment of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas.
Gail A ReifJared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas.
Darren P WallaceJared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas.ORCID 0000-0003-4616-7669
Gunda I GeorgDepartment of Medicinal Chemistry and Institute for Therapeutics Discovery and Development, University of Minnesota, Minneapolis, Minnesota.
Sudhakar R JakkarajDepartment of Medicinal Chemistry and Institute for Therapeutics Discovery and Development, University of Minnesota, Minneapolis, Minnesota.
Joseph S TashDepartment of Molecular and Integrated Physiology, University of Kansas Medical Center, Kansas City, Kansas.
Alan S L YuJared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas.ORCID 0000-0002-1776-2533
Xiaogang LiJared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas.ORCID 0000-0001-8135-342X
James P CalvetDepartment of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas.ORCID 0000-0001-5928-9820
University of Kansas Medical Center · USMayo Clinic · USUniversity of Minnesota · US
Funding
Using Integrated Omics to Identify Dysfunctional Genetic Mechanisms Influencing Schizophrenia and Sleep DisturbancesP20GM130423 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Kalyani Pyaram, Steven Allan Soper · 2019 to 2026
$21.5M
Polycystin Function Resource Development CoreU54DK126126 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI DARREN P. WALLACE · 2020 to 2026
$5.8M
Pilot and Feasibility CoreP30DK106912 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI CALVET, JAMES P · 2015 to 2019
$5.5M
Role of Periostin in Polycystic Kidney DiseaseR01DK081579 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI WALLACE, DARREN P. · 2009 to 2018
$3.0M
The crosstalk of DNA and lysine methyltransferases in ADPKD.R01DK126662 · NIDDK · MAYO CLINIC ROCHESTER · PI Xiaogang Li · 2020 to 2026
Autosomal dominant polycystic kidney disease (ADPKD) is a debilitating renal neoplastic disorder with limited treatment options. It is characterized by the formation of large fluid-filled cysts that develop from kidney tubules through abnormal cell proliferation and cyst-filling fluid secretion driven by cAMP-dependent Cl
Indexed as
CystsPolycystic Kidney, Autosomal DominantPolycystic Kidney DiseasesActinsAnimalsCarboxylic AcidsCell ProliferationCells, CulturedColforsinCyclin-Dependent Kinase 4Cystic Fibrosis Transmembrane Conductance RegulatorEGF Family of ProteinsHeat-Shock ProteinsHumansIndazolesKidneyActinsCarboxylic AcidsColforsinCyclin-Dependent Kinase 4Cystic Fibrosis Transmembrane Conductance RegulatorEGF Family of ProteinsgamendazoleHeat-Shock ProteinsIndazoleslonidaminePkhd1 protein, mouseProto-Oncogene Proteins c-aktReceptors, Cell Surfaceactin cytoskeletonautosomal dominant polycystic kidney diseasecell motilitycell proliferationcystic fibrosis transmembrane conductance regulatorfluid secretionheat shock protein 90metanephric organ culture
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
The lonidamine derivative H2-gamendazole reduces cyst formation in polycystic kidney disease. · full record | OpenQuestion