ArticleAngewandte Chemie (International ed. in English)2022
Simultaneous Generation of Methyl Esters and CO in Lignin Transformation.
Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 20 citations in OpenAlex.
- Iron(iii) sulfate/HRSC advances · 2026Article
- Biphasic Solar Reforming of Lignin to Aromatics and CO for In Situ Carbonylation of Organics.Journal of the American Chemical Society · 2026Article
- Single-Atom Iron-Catalyzed Oxidative Esterification: From Methylarenes to the Upcycling of Polystyrene and Lignin-Derived Feedstocks.Angewandte Chemie (International ed. in English) · 2026Article
- Synthesis of aromatic amides from lignin and its derivatives.Nature communications · 2025Article
- Lignin-Based Mucus-Mimicking Antiviral Hydrogels with Enzyme Stability and Tunable Porosity.ACS applied materials & interfaces · 2025Article
- Tandem catalysis enables chlorine-containing waste as chlorination reagents.Nature chemistry · 2024Article
- Simultaneous Generation of Methyl Esters and CO in Lignin Transformation.Angewandte Chemie (International ed. in English) · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lignin is an abundant renewable carbon source. Due to its complex structure, utilization of lignin is very challenging. Herein, we describe an efficient strategy for the simultaneous utilization of lignin, in which the methoxy groups in lignin react with carboxylic acids to generate methyl carboxylates and the other alkyl and phenyl carbons react with oxygen to predominantly form CO that can be used directly in carbonylation reactions. The method was applied to the methylation of various functionalized aryl and alkyl carboxylic acids, including natural compounds, to produce valuable chemicals, including pharmaceuticals. No solid or liquid residues remain after the reaction. Mechanistic studies demonstrate that a well-ordered C-C and C-O bond activation sequence takes place to realize total transformation of lignin. This work opens a way for transformation of the entire lignin polymer into valuable products, exemplified by the synthesis of the pharmaceutical, Ramipril, on a gram scale.
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