Evidence map›Paper›PMID 35979600›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2022

Design, synthesis, and biological screening of a series of 4'-fluoro-benzotriazole-acrylonitrile derivatives as microtubule-destabilising agents (MDAs).

Federico Riu, Roberta Ibba, Stefano Zoroddu, Simona Sestito, Michele Lai, Sandra Piras, Luca Sanna, Valentina Bordoni, Luigi Bagella, Antonio Carta

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Federico RiuDepartment of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy.
Roberta IbbaDepartment of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy.
Stefano ZorodduDepartment of Biomedical Sciences, University of Sassari, Sassari, Italy.
Simona SestitoDepartment of Chemical, Physical, Mathematical and Natural Sciences, University of Sassari, Sassari, Italy.
Michele LaiDepartment of Translational Medicine and New Technologies in Medicine and Surgery, Retrovirus Centre, University of Pisa, Pisa, Italy.
Sandra PirasDepartment of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy.
Luca SannaDepartment of Biomedical Sciences, University of Sassari, Sassari, Italy.
Valentina BordoniDepartment of Biomedical Sciences, University of Sassari, Sassari, Italy.
Luigi BagellaDepartment of Biomedical Sciences, University of Sassari, Sassari, Italy.
Antonio CartaDepartment of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AcrylonitrileAntineoplastic AgentsCell Line, TumorCell ProliferationColchicineDrug Screening Assays, AntitumorHeLa CellsHumansLigandsMicrotubulesMolecular Docking SimulationStructure-Activity RelationshipTriazolesTubulinTubulin ModulatorsAcrylonitrileAntineoplastic AgentsbenzotriazoleColchicineLigandsTriazolesTubulinTubulin Modulatorsantiproliferative compoundsBenzotriazole-acrylonitrilecell growth inhibitioncolchicine-binding site inhibitorsmolecular docking

Identifiers

PMID35979600
PMCPMC9397482

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.