ReviewFrontiers in pediatrics2022
Iron deficiency anemia and thrombosis risk in children-revisiting an old hypothesis.
Review in Frontiers in pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- Transient Ischemic Attack in a Child With Severe Iron Deficiency Anaemia and Thrombocytopenia: Case Report.Journal of paediatrics and child health · 2026Article
- Understanding Pediatric Stroke: Etiology, Diagnosis, and Management in Children Under 15 Years.Cureus · 2026Review
- Coagulation abnormalities in pediatric anemia clinical and laboratory correlates for risk stratification and risk assessment.Annals of medicine and surgery (2012) · 2026Review
- Prediction model for leaflet thrombosis in patients undergoing transcatheter aortic valve implantation: the EFFORT study.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Observational
- Thrombosis and Anemia in Pediatric Inflammatory Bowel Disease: Pathophysiology, Clinical Impact and Future Directions.International journal of molecular sciences · 2025Review
- Etiologic spectrum and neurological outcomes in pediatric arterial ischemic stroke and cerebral sinovenous thrombosis: A 15-Year retrospective study at a tertiary hospital.Acta neurologica Belgica · 2025Article
- Understanding Acute Heavy Menstrual Bleeding: Insights From an Interdisciplinary Panel.O&G open · 2025Article
- Increased Transferrin Concentrations Are Not Associated With Thrombosis in People Living at High Altitude.Journal of hematology · 2025Article
- Case Report: Cerebral venous sinus thrombosis in the setting of iron deficiency anemia and a high level of lipoprotein (a) in a child.Frontiers in pediatrics · 2025Article
- Cardiovascular Comorbidities in COVID-19: Comprehensive Analysis of Key Topics.Interactive journal of medical research · 2024Article
- Association Between Congenital Heart Disease and Stroke: Insights from a National Database.Pediatric cardiology · 2024Article
- Increased transferrin protects from thrombosis in Chuvash erythrocytosis.American journal of hematology · 2023Article
- Review
- Associated factors in pediatric patients admitted with severe iron-deficiency anemia in the last seven years - the experience of a single pediatric unit.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieObservational
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron deficiency anemia has a high prevalence in children and has repeatedly been implicated as a risk factor for arterial and venous thrombosis. As an effective therapy for iron deficiency anemia is available, understanding the association between this form of anemia and the potentially severe thrombosis phenotype is of major clinical interest. Recent findings shed light on pathophysiology of hypercoagulability resulting from iron-restricted erythropoiesis. Specifically, an animal model of induced iron deficiency allowed identifying multiple mechanisms, by which iron deficiency anemia results in increased thrombus formation and thrombus progression both in arterial and venous thrombosis. These findings complement and support conclusions derived from clinical data. The purpose of this mini review is to summarize current evidence on the association of iron deficiency anemia and thrombosis. We want to increase the awareness of iron deficiency as a risk factor for thrombosis in the pediatric population. We discuss how novel pathophysiological concepts can be translated into the clinical settings and suggest clinical studies on prevention and treatment strategies in high-risk patient groups.
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