Evidence map›Paper›PMID 35979363›Full record

ArticleFrontiers in immunology2022

A gene expression map of host immune response in human brucellosis.

Ioannis Mitroulis, Akrivi Chrysanthopoulou, Georgios Divolis, Charalampos Ioannidis, Maria Ntinopoulou, Athanasios Tasis, Theocharis Konstantinidis, Christina Antoniadou, Natalia Soteriou, George Lallas and 10 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Microorganisms · 2025
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  6. IL-1b-Bearing NETs: Bridging Inflammation to Early Cirrhosis in Hepatitis B.International journal of molecular sciences · 2025
    Article
  7. Article
  8. TheInternational journal of molecular sciences · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 8 institutions in 2 countries.

Ioannis MitroulisLaboratory of Molecular Hematology, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, Greece.
Akrivi ChrysanthopoulouLaboratory of Molecular Hematology, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, Greece.
Georgios DivolisBiomedical Research Foundation Academy of Athens, Center for Clinical, Experimental Surgery and Translational Research, Athens, Greece.
Charalampos IoannidisInstitute for Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Maria NtinopoulouLaboratory of Molecular Hematology, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, Greece.
Athanasios TasisLaboratory of Molecular Hematology, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, Greece.
Theocharis KonstantinidisLaboratory of Molecular Hematology, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, Greece.
Christina AntoniadouLaboratory of Molecular Hematology, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, Greece.
Natalia SoteriouR&D Department, P. Zafiropoulos S.A., Athens, Greece.
George LallasR&D Department, P. Zafiropoulos S.A., Athens, Greece.
Stella MitkaSchool of Biomedical Sciences, International Hellenic University, Thessaloniki, Greece.
Mathias LescheDRESDEN-concept Genome Center, Center for Molecular and Cellular Bioengineering, Technische Universität Dresden, Dresden, Germany.
Andreas DahlDRESDEN-concept Genome Center, Center for Molecular and Cellular Bioengineering, Technische Universität Dresden, Dresden, Germany.
Stephanie GembardtInstitute for Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Maria PanopoulouLaboratory of Microbiology, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, Greece.
Paschalis SiderasBiomedical Research Foundation Academy of Athens, Center for Clinical, Experimental Surgery and Translational Research, Athens, Greece.
Ben WielockxInstitute for Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Ünal CoskunInstitute for Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Konstantinos RitisLaboratory of Molecular Hematology, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, Greece.
Panagiotis SkendrosLaboratory of Molecular Hematology, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, Greece.
Technische Universität Dresden · DEDemocritus University of Thrace · GRUniversity Hospital of Alexandroupolis · GRAcademy of Athens · GRStamatopoulos and Associates (Greece) · GRCenter for Systems Biology Dresden · DEInternational Hellenic University · GRUniversity of Ioannina · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brucellosis is a common zoonotic disease caused by intracellular pathogens of the genus

Indexed as

Brucella abortusBrucellosisGene ExpressionHumansImmunity, InnateLeukocytes, Mononuclearbrucellosisimmunitymacrophagesperipheral blood mononuclear cellspolymorphonuclear neutrophilstranscriptomics

Identifiers

PMID35979363
PMCPMC9376622
OpenAlexW4289170224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.