Evidence map›Paper›PMID 35979231›Full record

ArticleFrontiers in pharmacology2022

Population Pharmacokinetics of Cyclosporine in Chinese Pediatric Patients With Acquired Aplastic Anemia.

Xuan Gao, Zhu-Li Bian, Xiao-Hong Qiao, Xiao-Wen Qian, Jun Li, Guo-Mei Shen, Hui Miao, Yi Yu, Jian-Hua Meng, Xiao-Hua Zhu and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Xuan GaoOutpatient and Emergency Management Office, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
Zhu-Li BianDepartment of Pediatrics, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Xiao-Hong QiaoDepartment of Pediatrics, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Xiao-Wen QianDepartment of Hematology and Oncology, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
Jun LiDepartment of Hematology and Oncology, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
Guo-Mei ShenOutpatient and Emergency Management Office, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
Hui MiaoDepartment of Hematology and Oncology, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
Yi YuDepartment of Hematology and Oncology, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
Jian-Hua MengDepartment of Hematology and Oncology, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
Xiao-Hua ZhuDepartment of Hematology and Oncology, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
Jun-Ye JiangDepartment of Hematology and Oncology, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
Jun LeDepartment of Hematology and Oncology, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
Ling YuDepartment of Hematology and Oncology, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
Hong-Sheng WangDepartment of Hematology and Oncology, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
Xiao-Wen ZhaiDepartment of Hematology and Oncology, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
Children's Hospital of Fudan University · CNTongji Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cyclosporine (CsA) is a component of the first-line treatment for acquired aplastic anemia (acquired AA) in pediatric patients. This study aimed to develop a population pharmacokinetic (PK) model of CsA in Chinese pediatric patients with acquired AA to inform individual dosage regimens. A total of 681 CsA whole blood concentrations and laboratory data of 157 pediatric patients with acquired AA were retrospectively collected from two hospitals in Shanghai. A nonlinear mixed-effect model approach was used to build the population PK model. Potential covariate effects of age, body weight, and biochemical measurements (renal and liver functions) on CsA PK disposition were evaluated. Model fit was assessed using the basic goodness of fit and a visual predictive check. The CsA concentration data were accurately described using a two-compartment disposition model with first-order absorption and elimination. Body weight value was implemented as a fixed allometric function on all clearance and volume of distribution parameters. Total bilirubin level was identified as a significant covariate on apparent clearance (CL/F), with a 1.07% reduction per 1 nmol/L rise in total bilirubin level. The final estimates for CL/F and central volume (Vc/F) were 29.1 L/h and 325 L, respectively, for a typical 28 kg child. Other covariates (e.g., gender, age, albumin, hemoglobin, hematocrit, serum creatinine, and concomitant medication) did not significantly affect the PK properties of CsA. This population PK model, along with a maximum a

Indexed as

acquired aplastic anemiacyclosporineNONMEMpediatric patientspopulation pharmacokinetics

Identifiers

PMID35979231
PMCPMC9377374
OpenAlexW4288040488

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.