Evidence map›Paper›PMID 35979196›Full record

ArticleResearch and practice in thrombosis and haemostasis2022

Patients with myeloproliferative neoplasms and COVID-19 have increased rates of arterial thrombosis.

Orly Leiva, Umberto Campia, Julia Snyder, Briana M Barns, Samantha Rizzo, Candrika D Khairani, Andrew Brunner, Hanny Al-Samkari, Rebecca Karp Leaf, Rachel Rosovsky and 6 more

Open access · goldAbstract read
In one paragraph

Article in Research and practice in thrombosis and haemostasis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Orly LeivaDivision of Cardiovascular Medicine, Department of Medicine New York University Langone Health New York City New York USA.ORCID https://orcid.org/0000-0002-3006-6380
Umberto CampiaDivision of Cardiovascular Medicine, Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts USA.
Julia SnyderDivision of Cardiovascular Medicine, Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts USA.
Briana M BarnsDivision of Cardiovascular Medicine, Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts USA.
Samantha RizzoDivision of Cardiovascular Medicine, Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts USA.
Candrika D KhairaniDivision of Cardiovascular Medicine, Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts USA.
Andrew BrunnerDivision of Hematology and Oncology, Department of Medicine Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA.
Hanny Al-SamkariDivision of Hematology and Oncology, Department of Medicine Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA.ORCID https://orcid.org/0000-0001-6175-1383
Rebecca Karp LeafDivision of Hematology and Oncology, Department of Medicine Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA.
Rachel RosovskyDivision of Hematology and Oncology, Department of Medicine Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA.ORCID https://orcid.org/0000-0002-2392-7365
Katayoon GoodarziDivision of Hematology and Oncology, Department of Medicine Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA.
Larissa BornikovaDivision of Hematology and Oncology, Department of Medicine Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA.
Amir FathiDivision of Hematology and Oncology, Department of Medicine Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA.
Samuel Z GoldhaberDivision of Cardiovascular Medicine, Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts USA.
Gabriela HobbsDivision of Hematology and Oncology, Department of Medicine Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA.
Gregory PiazzaDivision of Cardiovascular Medicine, Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts USA.
Brigham and Women's Hospital · USHarvard University · US

Funding

Antiangiogenic Therapy to Reduce Bleeding and Improve Health-Related Quality of Life in Hereditary Hemorrhagic TelangiectasiaK23HL159313 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Hanny T Al-Samkari · 2022 to 2026
$999k
NHLBI NIH HHS K23 HL159313
6 · The paper itself

Abstract

Background: Both coronavirus disease-2019 (COVID-19) and myeloproliferative neoplasms (MPNs) are associated with systemic inflammation and risk of thrombosis. Risk of thrombosis in patients with COVID with and without MPNs has not been extensively studied. Methods: Retrospective cohort study of 44 patients with MPNs and 1114 patients without MPNs positive for SARS-COV-2. Outcomes were arterial thrombosis (AT), venous thromboembolism (VTE), bleeding, and death. Time-to-event analysis was performed using competing risk regression model and Cox proportional hazards. Results: AT occurred more frequently in patients with MPN (7% vs. 1%, Conclusions: Among patients with COVID-19, MPN patients had higher risk of arterial thrombosis but not VTE, bleeding, and death compared with non-MPN patients. Larger studies are needed to confirm our findings given the limited sample size.

Indexed as

arterial thrombosiscoronavirusCOVID‐19myeloproliferative neoplasms

Identifiers

PMID35979196
PMCPMC9372283
OpenAlexW4295067817

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.