Evidence map›Paper›PMID 35979190›Full record

ArticleInflammatory intestinal diseases2022

Impact of Diagnostic Delay on Disease Course in Pediatric- versus Adult-Onset Patients with Ulcerative Colitis: Data from the Swiss IBD Cohort.

Alain M Schoepfer, Vu Dang Chau Tran, Jean-Benoit Rossel, Christiane Sokollik, Johannes Spalinger, Ekaterina Safroneeva, Thea von Graffenried, Sébastien Godat, Dieter Hahnloser, Stephan R Vavricka and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inflammatory intestinal diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Alain M SchoepferDivision of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Lausanne, Switzerland.
Vu Dang Chau TranDivision of Pediatric Gastroenterology, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Lausanne, Switzerland.
Jean-Benoit RosselClinical Trials Unit, Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Christiane SokollikDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, University Children's Hospital, University of Bern, Bern, Switzerland.
Johannes SpalingerDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, University Children's Hospital, University of Bern, Bern, Switzerland.
Ekaterina SafroneevaInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Thea von GraffenriedDivision of Pediatric Gastroenterology, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Lausanne, Switzerland.
Sébastien GodatDivision of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Lausanne, Switzerland.
Dieter HahnloserDivision of Visceral Surgery, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Lausanne, Switzerland.
Stephan R VavrickaDivision of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
Christian BraeggerNutrition Research Unit, University Children's Hospital Zurich, Zurich, Switzerland.
Andreas NydeggerDivision of Pediatric Gastroenterology, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Lausanne, Switzerland.
University Hospital of Lausanne · CHUniversity of Bern · CHUniversity Children's Hospital Zurich · CHUniversity Hospital of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Given the lack of data, we aimed to assess the impact of the length of diagnostic delay on the natural history of ulcerative colitis (UC) in pediatric (diagnosed <18 years) and adult patients (diagnosed ≥18 years). Methods: Data from the Swiss Inflammatory Bowel Disease Cohort Study were analyzed. Diagnostic delay was defined as the interval between the first appearance of UC-related symptoms until diagnosis. Logistic regression modeling evaluated the appearance of the following complications in the long term according to the length of diagnostic delay: colonic dysplasia, colorectal cancer, UC-related hospitalization, colectomy, and extraintestinal manifestations (EIMs). Results: A total of 184 pediatric and 846 adult patients were included. The median diagnostic delay was 4 [IQR 2-7.5] months for the pediatric-onset group and 3 [IQR 2-10] months for the adult-onset group ( Conclusions: As colorectal cancer and EIMs are associated with considerable morbidity and costs, every effort should be made to reduce diagnostic delay in UC patients.

Indexed as

ColectomyDiagnostic delayInflammatory bowel diseaseNatural historyUlcerative colitis

Identifiers

PMID35979190
PMCPMC9294935
OpenAlexW4200336210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.