Evidence map›Paper›PMID 35979144›Full record

ArticleFaculty reviews2022

Adhesion-independent topography-based leukocyte migration.

Peter Friedl, Konstantinos Konstantopoulos, Erik Sahai, Orion Weiner

Open access · diamondAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Faculty reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Monocytes use protrusive forces to generate migration paths in viscoelastic collagen-based extracellular matrices.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

Peter FriedlRadboud University Medical Centre.ORCID https://orcid.org/0000-0002-0119-4041
Konstantinos KonstantopoulosJohns Hopkins University.ORCID https://orcid.org/0000-0003-2623-1459
Erik SahaiThe Francis Crick Institute.ORCID https://orcid.org/0000-0002-3932-5086
Orion WeinerUniversity of California, San Francisco.ORCID https://orcid.org/0000-0002-1778-6543
Johns Hopkins University · USRadboud University Nijmegen · NLThe Francis Crick Institute · GBUniversity of California, San Francisco · US

Funding

Cellular Decision Making Diversity SupplementR35GM118167 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Orion D Weiner · 2016 to 2026
$10.3M
Austrian Science Fund FWF P 29911NIGMS NIH HHS R35 GM118167
6 · The paper itself

Abstract

Cells need to couple intracellular actin flows with the substrate to generate forward movement. This has traditionally been studied in the context of specific transmembrane receptors, particularly integrin adhesion receptors, which link extracellular adhesive molecules to the actin cytoskeleton. However, leukocytes and other cells can also migrate using integrin-independent strategies both

Indexed as

Actinadhesioncellsleukocyte

Identifiers

PMID35979144
PMCPMC9354731
OpenAlexW4286203240

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.