Evidence map›Paper›PMID 35979125›Full record

ArticleWorld journal of clinical cases2022

Adrenocorticotropic hormone-secreting pancreatic neuroendocrine carcinoma with multiple organ infections and widespread thrombosis: A case report.

Akihiro Yoshihara, Kota Nishihama, Chisa Inoue, Yuko Okano, Kazuhito Eguchi, Soichiro Tanaka, Kanako Maki, Valeria Fridman D'Alessandro, Atsuro Takeshita, Taro Yasuma and 4 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of clinical cases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Ectopic adrenocorticotropic hormone syndrome withThe Journal of international medical research · 2026
    Review
  2. Unusual infections and thrombotic events in Cushing's syndrome.Journal of endocrinological investigation · 2025
    Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Akihiro YoshiharaDepartment of Diabetes and Endocrinology, Japan Community Health care Organization Yokkaichi Hazu Medical Center, Yokkaichi 510-0016, Mie, Japan.
Kota NishihamaDepartment of Diabetes, Metabolism, and Endocrinology, Mie University, Tsu 514-8507, Mie, Japan.
Chisa InoueDepartment of Diabetes, Metabolism, and Endocrinology, Mie University, Tsu 514-8507, Mie, Japan.
Yuko OkanoDepartment of Diabetes, Metabolism, and Endocrinology, Mie University, Tsu 514-8507, Mie, Japan.
Kazuhito EguchiDepartment of Diabetes, Metabolism, and Endocrinology, Mie University, Tsu 514-8507, Mie, Japan.
Soichiro TanakaDepartment of Diabetes, Metabolism, and Endocrinology, Mie University, Tsu 514-8507, Mie, Japan.
Kanako MakiDepartment of Diabetes, Metabolism, and Endocrinology, Mie University, Tsu 514-8507, Mie, Japan.
Valeria Fridman D'AlessandroDepartment of Immunology, Mie University, Tsu 514-8507, Mie, Japan.
Atsuro TakeshitaDepartment of Immunology, Faculty and Graduate School of Medicine, Mie University, Tsu 514-8507, Mie, Japan.
Taro YasumaDepartment of Immunology and Department of Diabetes, Metabolism, and Endocrinology, Mie University, Tsu 514-8507, Mie, Japan.
Mei UemuraDepartment of Diabetes, Metabolism, and Endocrinology, Mie University, Tsu 514-8507, Mie, Japan.
Toshinari SuzukiDepartment of Diabetes, Metabolism, and Endocrinology, Mie University, Tsu 514-8507, Mie, Japan.
Esteban C GabazzaDepartment of Immunology, Mie University School of Medicine, Mie University, Tsu 514-8507, Mie, Japan. gabazza@doc.medic.mie-u.ac.jp.
Yutaka YanoDepartment of Diabetes, Metabolism, and Endocrinology, Mie University, Tsu 514-8507, Mie, Japan.
Mie University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEctopic adrenocorticotropic hormone (ACTH)-secreting neuroendocrine tumors are rare diseases. Patients with ACTH-secreting pancreatic neuroendocrine carcinomas have a poor prognosis. Infections and coagulopathies have been reported as the cause of death. However, detailed clinical descriptions of the morbid complications of ACTH-secreting neuroendocrine carcinomas have not been reported. CASE SUMMARY: A 78-year-old Japanese woman consulted a medical center due to systemic edema and epigastric discomfort. Laboratory analysis revealed hypercortisolemia with increased ACTH secretion without diurnal variation in serum cortisol level. An enhanced computed tomography (CT) scan revealed a 3-cm tumor in the pancreatic head. The cytological material from endoscopic ultrasound-guided fine-needle aspiration was compatible with ACTH-secreting pancreatic neuroendocrine carcinoma. The Ki-67 index was 40%. She was transferred to Mie University Hospital for surgical treatment. The patient was diagnosed with urinary tract infection, cytomegalovirus hepatitis, esophageal candidiasis, pulmonary infiltrates suspicious for

conclusionACTH-secreting pancreatic neuroendocrine neoplasm is a rare disease with a very poor prognosis. The clinical course and acute complications of the tumor remain unreported. Here we report the clinical course of a rapidly progressive case of ACTH-secreting pancreatic neuroendocrine tumor that developed infectious complications due to many types of pathogens in multiple organs, widespread thromboses, pulmonary embolism, and disseminated intravascular coagulation.

Indexed as

Case reportCushing's syndromeEctopic adrenocorticotropic hormone syndromeInfectionsNeuroendocrine tumorsPneumocystis pneumoniaPulmonary embolism

Identifiers

PMID35979125
PMCPMC9258352
OpenAlexW4281723004

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.