ArticleBiological psychiatry global open science2022
Prenatal Exposure to Air Pollution and Early-Life Stress Effects on Hippocampal Subregional Volumes and Associations With Visuospatial Reasoning.
Article in Biological psychiatry global open science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Review
- Effects of combined prenatal exposure to air pollution and maternal stress on social behavior and oxytocin and vasopressin systems in male and female mice.Journal of neuroendocrinology · 2026Article
- In utero air pollution exposure and pre- and postnatal brain development: a review.Neuroscience applied · 2026Review
- Microglia as critical mediators linking perinatal immune stress to mental health trajectories.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Prenatal environmental risk for adolescent attention, thought, and substance use problems: A mixtures approach to coexposure and psychiatric comorbidities.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- The Impact of Early Life Exposure to Air Pollution on the Brain: A Diffusion MRI Study in 10-13-Year-Old Children With and Without ADHD Diagnosis.Human brain mapping · 2025Article
- Sources of outdoor air pollution exposure and child brain network development across the United States.bioRxiv : the preprint server for biology · 2025Article
- Effects of combined prenatal exposure to air pollution and maternal stress on social behavior and oxytocin and vasopressin systems in male and female mice.bioRxiv : the preprint server for biology · 2025Article
- Annual Research Review: Exposure to environmental chemicals and psychosocial stress and the development of children's learning difficulties.Journal of child psychology and psychiatry, and allied disciplines · 2025Review
- The role of the hippocampus in working memory and word reading: Novel neural correlates of reading among youth living in the context of economic disadvantage.Developmental cognitive neuroscience · 2025Article
- Polycyclic aromatic hydrocarbon exposure effects on trajectories of maternal and adolescent mental health.Child and adolescent psychiatry and mental health · 2024Article
- Exposure to air pollution is associated with DNA methylation changes in sperm.Environmental epigenetics · 2024Article
- Dentate Gyrus Microstructure Is Associated With Resilience After Exposure to Maternal Stress Across Two Human Cohorts.Biological psychiatry · 2024Article
- Disparities in Toxic Chemical Exposures and Associated Neurodevelopmental Outcomes: A Scoping Review and Systematic Evidence Map of the Epidemiological Literature.Environmental health perspectives · 2023Article
- Environmental Toxicants and the Developing Brain.Biological psychiatry · 2023Review
- Impact of Socioeconomic Status on Amygdala and Hippocampus Subdivisions in Children and Adolescents.bioRxiv : the preprint server for biology · 2023Article
- The impact of child poverty on brain development: does money matter?Dementia & neuropsychologia · 2023Review
- Introduction to the Special Issue on the Exposome-Understanding Environmental Impacts on Brain Development and Risk for Psychopathology.Biological psychiatry global open science · 2022Article
- Effects of prenatal polycyclic aromatic hydrocarbons and childhood material hardship on reading achievement in school-age children: A preliminary study.Frontiers in psychology · 2022Article
- Bridging the environment and neurodevelopment for children's health: Associations between real-time air pollutant exposures and cognitive outcomes.Frontiers in psychology · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundChildren from economically distressed families and neighborhoods are at risk for stress and pollution exposure and potential neurotoxic sequelae. We examine dimensions of early-life stress affecting hippocampal volumes, how prenatal exposure to air pollution might magnify these effects, and associations between hippocampal volumes and visuospatial reasoning.
methodsFifty-three Hispanic/Latinx and/or Black children of ages 7 to 9 years were recruited from a longitudinal birth cohort for magnetic resonance imaging and cognitive assessment. Exposure to airborne polycyclic aromatic hydrocarbons was measured during the third trimester of pregnancy. Maternal report of psychosocial stress was collected at child age 5 and served as measures of early-life stress. Whole hippocampus and subfield volumes were extracted using FreeSurfer. Wechsler performance IQ measured visuospatial reasoning.
resultsMaternal perceived stress associated with smaller right hippocampal volume among their children (B = -0.57,
conclusionsPrenatal and early-life exposures to chemical and social stressors are likely compounding. Socioeconomic deprivation and disparities increase risk of these exposures that exert critical neurobiological effects. Developing deeper understandings of these complex interactions will facilitate more focused public health strategies to protect and foster the development of children at greatest risk of mental and physical effects associated with poverty.
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Registered trials
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