Evidence map›Paper›PMID 35978759›Full record

ArticleCureus2022

Acute Severe Seronegative Autoimmune Hepatitis With Undiagnosed Graves' Disease.

Mohammad B Memon, Patrick Duplan, Sindu Iska, Erik Slabaugh, JigneshKumar Patel, Shaival Thakore

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Mohammad B MemonGraduate Medical Education, HCA Florida Bayonet Point Hospital, Hudson, USA.
Patrick DuplanGraduate Medical Education, HCA Florida Bayonet Point Hospital, Hudson, USA.
Sindu IskaInternal Medicine, HCA Florida Bayonet Point Hospital, Hudson, USA.
Erik SlabaughInternal Medicine, HCA Florida Bayonet Point Hospital, Hudson, USA.
JigneshKumar PatelGastroenterology, HCA Florida Bayonet Point Hospital, Hudson, USA.
Shaival ThakoreInternal Medicine, HCA Florida Bayonet Point Hospital, Hudson, USA.
Boone Hospital Center · USBay Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmune hepatitis (AIH) is a progressive inflammatory condition hypothesized to be a T-lymphocyte (T-cell)-mediated immune response that commonly affects females more than males. Given its proposed mechanism associated with immune response, it is more likely to present with other autoimmune conditions, particularly autoimmune disorders associated with the thyroid. AIH can be difficult to diagnose as it is a diagnosis of exclusion. AIH lacks validated algorithms for proper diagnosis and can seldom present with negative antibodies. If not fully worked up, AIH may progress to cirrhosis and even increase the risk of malignancy. Therefore, a liver biopsy is a crucial step in the workup for AIH. We report a rare case of acute severe AIH associated with negative antibodies and undiagnosed Graves' disease.

Indexed as

acute fulminant hepatitisacute fulminant hepatitis with parenchymal collapseautoimmune hepatitisgraves’ diseasejaundiceseronegativeseronegative autoimmune hepatitistransaminitis

Identifiers

PMID35978759
PMCPMC9375963
OpenAlexW4285590926

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.