Evidence map›Paper›PMID 35978717›Full record

ArticleInorganics2021

Cytochrome c: Using Biological Insight toward Engineering an Optimized Anticancer Biodrug.

Louis J Delinois, Omar De León-Vélez, Adriana Vázquez-Medina, Alondra Vélez-Cabrera, Amanda Marrero-Sánchez, Christopher Nieves-Escobar, Daniela Alfonso-Cano, Delvin Caraballo-Rodríguez, Jael Rodriguez-Ortiz, Jemily Acosta-Mercado and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inorganics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. CytochromeSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 2 institutions in 1 country.

Louis J DelinoisDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA.
Omar De León-VélezDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA.
Adriana Vázquez-MedinaDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA.
Alondra Vélez-CabreraDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA.
Amanda Marrero-SánchezDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA.
Christopher Nieves-EscobarDepartment of Chemistry, University of Puerto Rico, Humacao Campus, Humacao, PR 00792, USA.
Daniela Alfonso-CanoDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA.
Delvin Caraballo-RodríguezDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA.
Jael Rodriguez-OrtizDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA.
Jemily Acosta-MercadoDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA.
Josué A Benjamín-RiveraDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA.ORCID 0000-0002-9460-9954
Kiara González-GonzálezDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA.
Kysha Fernández-AdornoDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA.
Lisby Santiago-PagánDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA.
Rafael Delgado-VergaraDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA.
Xaiomy Torres-ÁvilaDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA.
Andrea Maser-FigueroaDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA.
Gladimarys Grajales-AvilésDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA.
Glorimar I Miranda MéndezDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA.
Javier Santiago-PagánDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA.
Miguel Nieves-SantiagoDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA.
Vanessa Álvarez-CarrilloDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA.
Kai GriebenowDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA.ORCID 0000-0003-0495-9932
Arthur D TinocoDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA.ORCID 0000-0003-2825-5235
University of Puerto Rico at Río Piedras · PRUniversity of Puerto Rico at Humacao · PR

Funding

Upgrade Laboratories Facilities at UPR-Rio PiedrasR25GM061151 · NIGMS · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI CARBALLEIRA, NESTOR MANUEL · 2001 to 2023
$32.5M
RIO PIEDRAS MARC U*STAR DEVELOPMENT PROGRAMT34GM007821 · NIGMS · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI CARBALLEIRA, NESTOR MANUEL · 1985 to 2020
$20.3M
Fusing the commercial drugs triapine and deferasirox to create Ti(IV) anticancer compounds that inhibit the bioavailability of ironR21CA240997 · NCI · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI TINOCO, ARTHUR DAVID · 2020 to 2020
$370k
NCI NIH HHS R21 CA240997NIGMS NIH HHS R25 GM061151NIGMS NIH HHS T34 GM007821
6 · The paper itself

Abstract

The heme protein cytochrome c (Cyt c) plays pivotal roles in cellular life and death processes. In the respiratory chain of mitochondria, it serves as an electron transfer protein, contributing to the proliferation of healthy cells. In the cell cytoplasm, it activates intrinsic apoptosis to terminate damaged cells. Insight into these mechanisms and the associated physicochemical properties and biomolecular interactions of Cyt c informs on the anticancer therapeutic potential of the protein, especially in its ability to subvert the current limitations of small molecule-based chemotherapy. In this review, we explore the development of Cyt c as an anticancer drug by identifying cancer types that would be receptive to the cytotoxicity of the protein and factors that can be finetuned to enhance its apoptotic potency. To this end, some information is obtained by characterizing known drugs that operate, in part, by triggering Cyt c induced apoptosis. The application of different smart drug delivery systems is surveyed to highlight important features for maintaining Cyt c stability and activity and improving its specificity for cancer cells and high drug payload release while recognizing the continuing limitations. This work serves to elucidate on the optimization of the strategies to translate Cyt c to the clinical market.

Indexed as

cytochrome cintrinsic apoptosissmart drug delivery systemstherapeutic proteins

Identifiers

PMID35978717
PMCPMC9380692
OpenAlexW3211545678

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.