Evidence map›Paper›PMID 35978680›Full record

ArticleACS medicinal chemistry letters2022

Small-Molecule Inhibitors of the MLL1 CXXC Domain, an Epigenetic Reader of DNA Methylation.

Hanuman P Kalmode, Izabella Podsiadly, Ashish Kabra, Adam Boulton, Prabhakar Reddy, Yan Gao, Christopher Li, John H Bushweller

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Virtual Special Issue: Epigenetics 2022.ACS pharmacology & translational science · 2022
    Article
  5. Virtual Special Issue: Epigenetics 2022.ACS medicinal chemistry letters · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Hanuman P KalmodeDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22903, United States.ORCID https://orcid.org/0000-0002-1577-5103
Izabella PodsiadlyDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22903, United States.
Ashish KabraDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22903, United States.
Adam BoultonDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22903, United States.
Prabhakar ReddyDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22903, United States.
Yan GaoDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22903, United States.
Christopher LiDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22903, United States.
John H BushwellerDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22903, United States.ORCID https://orcid.org/0000-0002-5386-1758
University of Virginia · US

Funding

Systems Biology of Bone Marrow Failure and MDS for Precision MedicineRC2DK122533 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI FIGUEROA, MARIA EUGENIA, FLEMING, MARK D · 2019 to 2023
$6.4M
Targeted Small Molecule Inhibitors for Inv(16) LeukemiaR01CA234478 · NCI · UNIVERSITY OF VIRGINIA · PI BUSHWELLER, JOHN HACKETT, CASTILLA, LUCIO H. · 2019 to 2023
$3.4M
AF9(MLLT3) Function in Leukemia and Normal HematopoiesisR01CA233749 · NCI · UNIVERSITY OF VIRGINIA · PI BUSHWELLER, JOHN HACKETT, FIGUEROA, MARIA EUGENIA · 2019 to 2023
$3.2M
Small Molecule Inhibitors of a Reader of DNA MethylationR21CA241005 · NCI · UNIVERSITY OF VIRGINIA · PI BUSHWELLER, JOHN HACKETT · 2019 to 2020
$378k
NCI NIH HHS R01 CA233749NCI NIH HHS R01 CA234478NCI NIH HHS R21 CA241005NIDDK NIH HHS RC2 DK122533
6 · The paper itself

Abstract

The CXXC domain is a reader of DNA methylation which preferentially binds to unmethylated CpG DNA motifs. Chromosomal translocations involving the

Identifiers

PMID35978680
PMCPMC9377001
OpenAlexW4284679704

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.