ArticleWorld journal of hepatology2022
DNA and RNA oxidative damage in hepatocellular carcinoma patients and mortality during the first year of liver transplantation.
Article in World journal of hepatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Patients with hepatocellular carcinoma that die during the first year of liver transplantation have high blood sFasL concentrations.World journal of clinical cases · 2023Article
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13 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundOxidative damage of DNA and RNA has been associated with mortality of patients with different diseases. However, there is no published data on the potential use of DNA and RNA oxidative damage to predict the prognosis of patients with hepatocellular carcinoma (HCC) undergoing liver transplantation (LT).
aimTo determine whether patients with increased DNA and RNA oxidative damage prior to LT for HCC have a poor LT prognosis.
methodsPatients with HCC who underwent LT were included in this observational and retrospective study. Serum levels of all three oxidized guanine species (OGS) were measured prior to LT since guanine is the nucleobase that forms DNA and RNA most prone to oxidation. LT mortality at 1 year was the end-point study.
resultsSurviving patients (
conclusionThe main new finding was that high serum OGS concentration prior to LT was associated with the mortality 1 year after LT in HCC patients.
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