Evidence map›Paper›PMID 35978558›Full record

ArticleJournal of primary care & community health

Unvaccinated Non-Elderly Adult Population Hospitalized for COVID-19: Risk for Severe Disease and Poor Outcomes.

Diana Jo, Anthony Sophonsri, Pamela Ny, Mimi Lou, Paul Nieberg, Kimberly Shriner, Annie Wong-Beringer

Open access · goldAbstract read
In one paragraph

Article in Journal of primary care & community health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Diana JoUniversity of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-2297-356X
Anthony SophonsriUniversity of Southern California, Los Angeles, CA, USA.
Pamela NyHuntington Hospital, Pasadena, CA, USA.
Mimi LouUniversity of Southern California, Los Angeles, CA, USA.
Paul NiebergHuntington Hospital, Pasadena, CA, USA.
Kimberly ShrinerHuntington Hospital, Pasadena, CA, USA.
Annie Wong-BeringerUniversity of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-3302-1409
University of Southern California · USHuntington Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionVaccination offers significant protection against hospitalization and death due to severe COVID-19. However, a significant portion of the nonelderly U.S. adult population remains unvaccinated.

methodsThis retrospective analysis of adult patients aged under 65 years hospitalized with PCR-confirmed SARS-CoV-2 between March and November 2021 assessed the age-biased risk for severe disease and outcome in non-elderly unvaccinated adults hospitalized for COVID-19. Main measures included predisposing risk factors, disease severity and progression, and outcomes in non-elderly adults compared between (1) vaccinated and unvaccinated individuals and (2) unvaccinated individuals grouped by 10-year age increment.

resultsTwo hundred nineteen non-elderly adults were included; of whom, 82.6% were unvaccinated. Overall, unvaccinated patients were more likely to be obese (60% vs 29%,

conclusionResults from our non-elderly cohort affirm the benefit of vaccination despite a subset requiring hospitalization for breakthrough infection. In unvaccinated non-elderly adults, risk for worse outcomes and severe disease increased substantially from middle age onward and provides strong support for vaccination efforts in this population.

Indexed as

COVID-19AdultHospitalizationHumansMiddle AgedOxygenRetrospective StudiesSARS-CoV-2Oxygenhospitalizationmortalitynon-elderlySARS-CoV-2unvaccinated

Identifiers

PMID35978558
PMCPMC9393585
OpenAlexW4292178098

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.